Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma

doi:10.1183/23120541.00314-2022

. 2022 Sep 26;8(3):00314-2022.

doi: 10.1183/23120541.00314-2022. eCollection 2022 Jul.

Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma

Fatemeh Moheimani^{1

2}, Nafeesa Shahdab^{1

2}, Stephen Cummings^{2

3}, Philip M Hansbro⁴, Christopher Ward⁵

Affiliations

¹ School of Health and Life Sciences, Teesside University, Middlesbrough, UK.
² National Horizons Centre, Teesside University, Darlington, UK.
³ Vice Chancellors' Office, Teesside University, Middlesbrough, UK.
⁴ Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia.
⁵ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

PMID: 36171982
PMCID: PMC9511154
DOI: 10.1183/23120541.00314-2022

Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma

Fatemeh Moheimani et al. ERJ Open Res. 2022.

. 2022 Sep 26;8(3):00314-2022.

doi: 10.1183/23120541.00314-2022. eCollection 2022 Jul.

Authors

Fatemeh Moheimani^{1

2}, Nafeesa Shahdab^{1

2}, Stephen Cummings^{2

3}, Philip M Hansbro⁴, Christopher Ward⁵

Affiliations

¹ School of Health and Life Sciences, Teesside University, Middlesbrough, UK.
² National Horizons Centre, Teesside University, Darlington, UK.
³ Vice Chancellors' Office, Teesside University, Middlesbrough, UK.
⁴ Centre for Inflammation, Centenary Institute and University of Technology Sydney, Faculty of Science, School of Life Sciences, Sydney, Australia.
⁵ Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, UK.

PMID: 36171982
PMCID: PMC9511154
DOI: 10.1183/23120541.00314-2022

Abstract

A differentiated air-liquid interface model shows that the airway epithelium plays a key role in response to respiratory viral infections in people with asthma https://bit.ly/3yDgiX1.

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Conflict of interest statement

Conflict of interest: None declared.

Cited by

Drugs Used in the Treatment of Viral Infections for the Prevention of Airway Remodeling in Asthma.
Wieczfinska J, Pawliczak R. Wieczfinska J, et al. Mediators Inflamm. 2025 Jul 24;2025:5526526. doi: 10.1155/mi/5526526. eCollection 2025. Mediators Inflamm. 2025. PMID: 40746413 Free PMC article. Review.

References

1. Ravi A, Chowdhury S, Dijkhuis A, et al. . Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma. ERJ Open Res 2022; 8: 00522-2021. doi:10.1183/23120541.00522-2021 - DOI - PMC - PubMed
1. Wark PA, Johnston SL, Bucchieri F, et al. . Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937–947. doi:10.1084/jem.20041901 - DOI - PMC - PubMed
1. Veerati PC, Troy NM, Reid AT, et al. . Airway epithelial cell immunity is delayed during rhinovirus infection in asthma and COPD. Front Immunol 2020; 11: 974. doi:10.3389/fimmu.2020.00974 - DOI - PMC - PubMed
1. Liu G, Philp AM, Corte T, et al. . Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther 2021; 225: 107839. doi:10.1016/j.pharmthera.2021.107839 - DOI - PubMed
1. Ward C, Pais M, Bish R, et al. . Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002; 57: 309–316. doi:10.1136/thorax.57.4.309 - DOI - PMC - PubMed

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[1] Ravi A, Chowdhury S, Dijkhuis A, et al. . Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma. ERJ Open Res 2022; 8: 00522-2021. doi:10.1183/23120541.00522-2021 - DOI - PMC - PubMed

[2] Ravi A, Chowdhury S, Dijkhuis A, et al. . Imprinting of bronchial epithelial cells upon in vivo rhinovirus infection in people with asthma. ERJ Open Res 2022; 8: 00522-2021. doi:10.1183/23120541.00522-2021 - DOI - PMC - PubMed

[3] Wark PA, Johnston SL, Bucchieri F, et al. . Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937–947. doi:10.1084/jem.20041901 - DOI - PMC - PubMed

[4] Wark PA, Johnston SL, Bucchieri F, et al. . Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus. J Exp Med 2005; 201: 937–947. doi:10.1084/jem.20041901 - DOI - PMC - PubMed

[5] Veerati PC, Troy NM, Reid AT, et al. . Airway epithelial cell immunity is delayed during rhinovirus infection in asthma and COPD. Front Immunol 2020; 11: 974. doi:10.3389/fimmu.2020.00974 - DOI - PMC - PubMed

[6] Veerati PC, Troy NM, Reid AT, et al. . Airway epithelial cell immunity is delayed during rhinovirus infection in asthma and COPD. Front Immunol 2020; 11: 974. doi:10.3389/fimmu.2020.00974 - DOI - PMC - PubMed

[7] Liu G, Philp AM, Corte T, et al. . Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther 2021; 225: 107839. doi:10.1016/j.pharmthera.2021.107839 - DOI - PubMed

[8] Liu G, Philp AM, Corte T, et al. . Therapeutic targets in lung tissue remodelling and fibrosis. Pharmacol Ther 2021; 225: 107839. doi:10.1016/j.pharmthera.2021.107839 - DOI - PubMed

[9] Ward C, Pais M, Bish R, et al. . Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002; 57: 309–316. doi:10.1136/thorax.57.4.309 - DOI - PMC - PubMed

[10] Ward C, Pais M, Bish R, et al. . Airway inflammation, basement membrane thickening and bronchial hyperresponsiveness in asthma. Thorax 2002; 57: 309–316. doi:10.1136/thorax.57.4.309 - DOI - PMC - PubMed

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Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma

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Key role of dysregulated airway epithelium in response to respiratory viral infections in asthma

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