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Review
. 2023 Feb;33(1):69-73.
doi: 10.1007/s10286-022-00897-8. Epub 2022 Sep 29.

Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension

Jens Jordan  1   2 , Italo Biaggioni  3 , Vasilios Kotsis  4 , Peter Nilsson  5 , Guido Grassi  6 , Artur Fedorowski  5   7 , Kazuomi Kario  8   9
Affiliations
Review

Consensus statement on the definition of orthostatic hypertension endorsed by the American Autonomic Society and the Japanese Society of Hypertension

Jens Jordan et al. Clin Auton Res. 2023 Feb.

Abstract

We propose a consensus definition of "an exaggerated orthostatic pressor response" in subjects in whom systolic blood pressure increases ≥ 20 mmHg when going from supine to standing posture. This definition can be extended for seated to standing measurements. We reserve the term "orthostatic hypertension" for when this pressor response leads to an upright systolic blood pressure ≥ 140 mmHg. We believe this consensus definition will help in the study of the pathophysiology, clinical impact, and potential treatment of these entities, and identification of patients who are at greater cardiovascular risk.

Keywords: Adrenergic; Autonomic nervous system; Baroreflex; Circadian rhythm; Orthostatic hypertension; Orthostatic pressor response; Sympathetic nervous system.

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Conflict of interest statement

J.J. served as advisor for Novo-Nordisk and Bayer, received research support from Boehringer-Ingelheim and Novo-Nordisk, and is co-founder of Eternygen GmbH. He is Editor-in-Chief of Clinical Autonomic Research and International Associate Editor of Hypertension Research but was not involved in editorial handling of this manuscript. I.B. is a consultant for Theravance Biopharma, Takeda Inc., and Amneal Pharmaceuticals, and has a patent for an automated abdominal binder to treat orthostatic hypotension. He is supported by NIH grants R01HL149386 and R01HL161095. V.K., P.N., G.G., and A.F. report no conflicts of interest. K.K. is Editor-in-Chief of Hypertension Research but was not involved in editorial handling of this manuscript.

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