Conflict of interest: L. Bonadies has nothing to declare. A. Papi reports grants from Chiesi, AstraZeneca, GSK, BI, Pfizer, Teva and Sanofi; consulting fees from Chiesi, AstraZeneca, GSK, Novartis, Sanofi, Iqvia, Avillion and Elpen Pharmaceuticals; honoraria from Chiesi, AstraZeneca, GSK, BI, Menarini, Novartis, Zambon, Mundipharma, Teva, Sanofi, Edmond Pharma, Iqvia, MSD, Avillion and Elpen Pharmaceuticals; all of the above were not related to this specific work. E. Baraldi reports consulting fees from AstraZeneca, Sanofi and Exobiologics outside the submitted work.