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Meta-Analysis
. 2022 Dec;109(6):643-647.
doi: 10.1111/ejh.13871. Epub 2022 Oct 5.

Efficacy of Helicobater pylori eradication in patients with diffuse large B-cell lymphoma of the stomach: A systematic review

Vincenzo De Francesco  1 , Raffaele Manta  2 , Riccardo Marmo  3 , Clelia Marmo  3 , Angela Rago  4 , Giulio Antonelli  5   6 , Cesare Hassan  7 , Angelo Zullo  8
Affiliations
Meta-Analysis

Efficacy of Helicobater pylori eradication in patients with diffuse large B-cell lymphoma of the stomach: A systematic review

Vincenzo De Francesco et al. Eur J Haematol. 2022 Dec.

Abstract

Objectives: The role of Helicobater pylori eradication in the treatment of high-grade diffuse large B-cell lymphoma (DLBCL) of the stomach is unclear.

Methods: We performed a systematic review and meta-analysis of currently available data. DLBCL-remission rate after eradication therapy, post-remission maintenance, and response rate in the case of additional oncological therapy were extracted.

Results: By considering data of seven studies, the DLBCL remission was achieved in 81 (53.3%; 95% CI = 45.3-61.2) out of 152 H. pylori eradicated patients. The regression rate did not differ between pure DLCBL and DLCBL with MALT component, between stage I and stage II disease, and between Caucasians and Asians. Disease regression was maintained in all patients after at a median of 63 months (range: 46-29) follow-up. In those non-responders, DLBLC remission after additional chemo-immunotherapy was achieved in 63 (98.4%; 95% CI = 95.4-100) out of 64 patients.

Conclusions: Data this systematic review suggest considering H. pylori eradication as first-line therapy to treat infected patients with early-stage, high-grade gastric lymphoma.

Keywords: Helicobacter pylori; chemo-immunotherapy; high-grade lymphoma; stomach.

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References

REFERENCES

    1. Peng JC, Zhong L, Ran ZH. Primary lymphomas in the gastrointestinal tract. J Dig Dis. 2015;16:169-176.
    1. Juárez-Salcedo LM, Sokol L, Chavez JC, Dalia S. Primary gastric lymphoma, epidemiology, clinical diagnosis, and treatment. Cancer Control. 2018;5:1073274818778256.
    1. Matysiak-Budnik T, Fabiani B, Hennequin C, et al. Gastrointestinal lymphomas: French Intergroup clinical practice recommendations for diagnosis, treatment and follow-up (SNFGE, FFCD, GERCOR, UNICANCER, SFCD, SFED, SFRO, SFH). Dig Liver Dis. 2018;50:124-131.
    1. Zucca E, Copie-Bergman C, Ricardi U, et al. Gastric marginal zone lymphoma of MALT type: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up. Ann Oncol. 2013;24 (Suppl 6):vi144-vi148.
    1. Seymour JF, Anderson RP, Bhatal PS. Regression of gastric lymphoma with therapy for Helicobacter pylori infection. Ann Intern Med. 1997;127:247.

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