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. 2022 Dec;144(6):1185-1187.
doi: 10.1007/s00401-022-02507-3. Epub 2022 Sep 29.

Prognostic significance of chromosome arm 1q gain and methylation class in molecularly defined diffuse leptomeningeal glioneuronal tumor

Jason Chiang  1 , Daniel C Moreira  2   3 , Xiaoyu Li  4 , Larissa V Furtado  4
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Prognostic significance of chromosome arm 1q gain and methylation class in molecularly defined diffuse leptomeningeal glioneuronal tumor

Jason Chiang et al. Acta Neuropathol. 2022 Dec.
No abstract available

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Figures

Fig. 1
Fig. 1
a Summary of the study cohort: 56.3% (18/32) of tumors had 1q gain. All tumors in methylation class 2 (MC-2, 9/32) had 1q gain; all tumors without 1q gain (Neg, 14/32) were in methylation class 1 (MC-1). Half of the tumors with 1q gain were in MC-1. There was no gender predilection within the subgroups (F female, M male). b No difference in age at diagnosis (ANOVA, p = 0.2839). c Kaplan–Meier plot of progression-free survival (PFS) of patients in the three subgroups (MC-1 and no 1q gain, MC-1 with 1q gain, and MC-2 with 1q gain) showed tumors with 1q gain had worse PFS. d Multivariable Cox regression analysis with PFS as the endpoint showed that 1q gain is the only significant prognosticator (HR hazard ratio, CI 95% confidence interval). e Kaplan–Meier plot of overall survival (OS) of patients in the three subgroups (MC-1 and no 1q gain, MC-1 with 1q gain, and MC-2 with 1q gain)
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References

    1. Chiang J, Dalton J, Upadhyaya SA, Patay Z, Qaddoumi I, Li X, Segura AD, Sharma S, Ismail A, Shurtleff SA, et al. Chromosome arm 1q gain is an adverse prognostic factor in localized and diffuse leptomeningeal glioneuronal tumors with BRAF gene fusion and 1p deletion. Acta Neuropathol. 2019;137:179–181. doi: 10.1007/s00401-018-1940-x. - DOI - PubMed
    1. Chiang JCH, Harreld JH, Orr BA, Sharma S, Ismail A, Segura AD, Ellison DW. Low-grade spinal glioneuronal tumors with BRAF gene fusion and 1p deletion but without leptomeningeal dissemination. Acta Neuropathol. 2017;134:159–162. doi: 10.1007/s00401-017-1728-4. - DOI - PMC - PubMed
    1. Deng MY, Sill M, Chiang J, Schittenhelm J, Ebinger M, Schuhmann MU, Monoranu CM, Milde T, Wittmann A, Hartmann C, et al. Molecularly defined diffuse leptomeningeal glioneuronal tumor (DLGNT) comprises two subgroups with distinct clinical and genetic features. Acta Neuropathol. 2018;136:239–253. doi: 10.1007/s00401-018-1865-4. - DOI - PubMed

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