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. 2022 Nov;41(11):1365-1370.
doi: 10.1007/s10096-022-04500-w. Epub 2022 Sep 30.

Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Ariel Kenig #  1   2 , Yonatan Oster #  2   3 , Ronit Cohen-Poradosu  4 , Klaris Reisenberg  5 , Anat Wieder-Finesod  6   7 , Mirit Hershman-Sarafov  8 , Ilana Oren  9 , Gabriel Weber  10   11 , Ron Dagan  12 , Gili Regev-Yochay  7   13 , Jacob Strahilevitz  14   15
Affiliations

Characteristics of endovascular pneumococcal infections; a decade of nationwide surveillance study

Ariel Kenig et al. Eur J Clin Microbiol Infect Dis. 2022 Nov.

Abstract

In order to characterize pneumococcal endovascular infection in the post-vaccination era, a retrospective nationwide study based on the Israeli Adult IPD database was conducted. Between 2010 and 2019, 0.6% (23 cases) of IPD cases were of endovascular type, occurring mainly in males (72.3%) with underlying medical conditions (78.2%). Additional pneumococcal source (10 patients) and concomitant infections were not uncommon. Penicillin and ceftriaxone susceptibility rates were 65.2% and 91.3%, respectively; 60.9% of the isolates were not covered by the pneumococcal conjugate vaccine. 21.7% of patients died during hospitalization. In conclusion, pneumococcal endovascular infections still carry significant morbidity and mortality.

Keywords: Endovascular infections; Infective endocarditis; Invasive pneumococcal disease; Streptococcus pneumoniae.

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