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. 2022 Sep 13:13:950826.
doi: 10.3389/fendo.2022.950826. eCollection 2022.

Gut microbiota is a potential goalkeeper of dyslipidemia

Lirong Lei  1   2   3 , Ning Zhao  1   2   3 , Lei Zhang  1   2   3 , Jiamei Chen  1   2   3 , Xiaomin Liu  1   2   3 , Shenghua Piao  1   2   3
Affiliations

Gut microbiota is a potential goalkeeper of dyslipidemia

Lirong Lei et al. Front Endocrinol (Lausanne). .

Abstract

Dyslipidemia, as a common metabolic disease, could cause atherosclerosis, coronary heart disease, stroke and other cardio-cerebrovascular diseases. It is mainly caused by the interaction of genetic and environmental factors and its incidence has increased for several years. A large number of studies have shown that gut microbiota disorder is related to the development of dyslipidemia closely. Especially its metabolites such as short-chain fatty acids, bile acids and trimethylamine N-oxide affect dyslipidemia by regulating cholesterol balance. In this paper, we systematically reviewed the literature and used knowledge graphs to analyze the research trends and characteristics of dyslipidemia mediated by gut microbiota, revealing that the interaction between diet and gut microbiota leads to dyslipidemia as one of the main factors. In addition, starting from the destruction of the dynamic balance between gut microbiota and host caused by dyslipidemia, we systematically summarize the molecular mechanism of gut microbiota regulating dyslipidemia and provide a theoretical basis for the treatment of dyslipidemia by targeting the gut microbiota.

Keywords: bile acids; dyslipidemia; gut microbiota; short chain fatty acid; trimethylamine N-oxide.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Research trend of the gut microbiota regulating dyslipidemia. (A) The number of published papers over the years includes the distribution of countries, (B) State relations, (C) Related keywords.
Figure 2
Figure 2
Schematic diagram of the interaction between diet, gut microbiota and lipid metabolism.
Figure 3
Figure 3
The gut microbiota regulates the pathway of dyslipidemia.
See this image and copyright information in PMC

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