A Case Report on Solitary Extramedullary Plasmacytoma of the Pleura

Abstract

Solitary plasmacytoma is an extremely rare form of plasma cell malignancy that presents as a single mass of monoclonal plasma cells located either intraosseous or extramedullary (extraosseous). Extramedullary plasmacytoma can affect any part of the body, but the most common sites of origin are the head and neck region. The involvement of pleura is very rare. Here, we are enlightening this rare presentation and making readers aware of the clinical presentation and management of this rare malignancy.

Keywords: extramedullary plasmacytoma; plasmacytoma; pleura; solitary bone plasmacytoma; solitary extramedullary plasmacytoma; solitary plasmacytoma.

Figure 1. Chest X-Ray showing finding suggestive of left pleural effusion

Figure 2. Pleural fluid cytology image

Pleural fluid cytology shows atypical plasma cells with binucleation and multinucleation (X 400)

Figure 3. Atypical plasma cells with binucleation and multinucleation (X 400)

Figure 4. Immunohistochemistry image 1 (X 400)

Plasma cells are positive for CD138.

Figure 5. Immunohistochemistry image 2 (X 200)

Plasma cells with predominant expression of lambda light chain.

Figure 6. Immunohistochemistry image 3 (X 200)

Plasma cell with less expression of kappa light chain.