Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2022 Sep 23;9(1):100054.
doi: 10.1016/j.acpath.2022.100054. eCollection 2022.

Educational Case: Rickets

Jonathan Light  1 , Michele Retrouvey  2 , Laurie L Wellman  3 , Richard M Conran  3
Affiliations
Case Reports

Educational Case: Rickets

Jonathan Light et al. Acad Pathol. .
No abstract available

Keywords: Bone; Children; Harrison sulcus; Musculoskeletal; Nonneoplastic disorder; Organ system pathology; Osteomalacia; Pathology competencies; Rickets; Varus deformity.

PubMed Disclaimer

Conflict of interest statement

The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

Figures

Fig. 1
Fig. 1
Frontal view of the left wrist, obtained as part of a rickets bone survey, shows cupping (small arrow) and fraying (large arrow) of the metaphysis of the left radius and ulna. The epiphyseal plate is widened (arrowhead).
Fig. 2
Fig. 2
Upright anteroposterior radiograph of the bilateral lower extremities demonstrates symmetric lateral bowing of the femora and tibias, without leg length discrepancy.
Fig. 3
Fig. 3
Anteroposterior radiograph of left lower extremity demonstrating metaphyseal fraying of the femur, tibia, and fibula (arrows). There is a widening of the epiphyseal plates of the femur and tibia (arrowheads).
Fig. 4
Fig. 4
An anteroposterior radiograph of the chest demonstrates cupping and fraying of the anterior ribs, at the costochondral junction (arrows).
Fig. 5
Fig. 5
Anteroposterior radiograph of the left lower extremity demonstrates osteopenia with marked bowing of the femur, tibia, and fibula. The femur may be shortened. There is no fracture or pseudoarthrosis, and no cupping or fraying of the metaphysis is observed.
Fig. 6
Fig. 6
A) Normal growth plate. (B) Section of costochondral junction in rickets. Notice overgrowth and disorganization of osteoid tissue (non-mineralized bone matrix) (H&E stain, intermediate magnification).
Fig. 7
Fig. 7
High-power field of non-mineralized osteoid. Notice that osteoid is stained pink. The normal trabeculae of mineralized bone stain violet (basophilic) (H&E stain, high magnification).
See this image and copyright information in PMC

References

    1. Knollmann-Ritschel B.E.C., Regula D.P., Borowitz M.J., Conran R., Prystowsky M.B. Pathology competencies for medical education and educational cases. Acad Pathol. 2017;4 doi: 10.1177/2374289517715040. - DOI - PMC - PubMed
    1. Shypailo R. 2020. Ollege of Medicine, Children's Nutrition Research Center, Body Composition Laboratory.http://www.bcm.edu/bodycomplab/BMIapp/BMI-calculator-kids.html Accessed.
    1. Suneja M., Szot J.F., LeBlond R.F., Brown D.D. DeGowin's Diagnostic Examination. eleventh ed. McGraw Hill; 2020. The chest: chest wall, pulmonary, and cardiovascular systems; the breasts.http://accessmedicine.mhmedical.com/content.aspx?aid=1174040801 Accessed.
    1. Horvai A. In: Robbins and Cotran Pathologic Basis of Disease. Tenth ed. Kumar V., Abbas A., Aster J.C., Turner J.R., editors. Elsevier; 2021. Bones, joints, and soft tissue tumors; pp. 1171–1216.
    1. Carpenter T. UpToDate; 2020. Overview of Rickets in Children: Evaluation.https://www.uptodate.com/contents/overview-of-rickets-in-children?search... Accessed.

Publication types

LinkOut - more resources