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Case Reports
. 2021 Dec 14;8(2):20210142.
doi: 10.1259/bjrcr.20210142. eCollection 2022 Mar 10.

Breast metastasis of a lung carcinoma

Ralph Khoury  1 , Margot Bucau  2 , Alexandra Bizot  3 , Antoine Khalil
Affiliations
Case Reports

Breast metastasis of a lung carcinoma

Ralph Khoury et al. BJR Case Rep. .

Abstract

Breast metastasis is a rare phenomenon (0.2-1.3%)1 compared to primary breast lesions. Several neoplasms have been reported to metastasize to the breast such as melanoma, lymphoma and lung cancer. In this article, we report a case of breast metastasis of lung cancer confirmed by biopsy and immunohistochemistry with CT and ultrasound imaging.

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Figures

Figure 1.
Figure 1.
Axial CT-scan showing the breast nodule (arrow) and the lung lesion (arrowheads).
Figure 2.
Figure 2.
Ultrasound image of the left breast showing the microlobulated hypoechoic nodule (star) with posterior enhancement and the biopsy needle (arrow).
Figure 3.
Figure 3.
Figure grouping the HES stains and the anti-TTF1 immunostaining of the lung and breast specimen. (a) HES staining, magnification x100: proliferation of cells in the chorion with atypical large nuclei under a normal bronchial epithelium. The cells are poorly visible due to crushing artifacts. (b) Anti-TTF1 immunostaining, x100 magnification: tumor cells are TTF1+. (c) HES staining, 100x magnification: invasionof the breast parenchyma by a tumor with large, atypical cells. (a) Anti-TTF1 immunostaining, x100 magnification: tumor cells invading the breast are also TTF1+. HES, hematein, eosin, saffron; TTF1, thyroid transcriptase factor 1.
See this image and copyright information in PMC

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