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. 2022 Dec;37(12):2459-2460.
doi: 10.1002/mds.29227. Epub 2022 Sep 29.

Striatal Development in Early-Onset Huntington's Disease

Jordan L Schultz  1   2 , Eric A Epping  1 , Ellen van der Plas  1 , Vincent A Magnotta  1   3 , Peggy C Nopoulos  1   2   4
Affiliations

Striatal Development in Early-Onset Huntington's Disease

Jordan L Schultz et al. Mov Disord. 2022 Dec.
No abstract available

Keywords: Huntington's disease; children; neurodevelopment.

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Figures

Figure 1:
Figure 1:. Assessment of Striatal Volume Amongst HD Children with Long CAG Repeats
A) The mean striatal volume of the pre-EOHD children was significantly elevated compared to matched GNE participants. The large circles represent the adjusted group means and the 95% confidence interval. B) A participant with a CAG of 73 who participated in the at-risk study from age 6–12 and their striatal volume is compared to a group of GNE participants comparable in age and matched for sex. At the age of 6, the participant was far from their predicted motor onset and had a striatal volume that was comparable to the GNE group.This participant’s striatal volume decreased quickly and they received a diagnosis of JOHD before the age of 12. Their trajectory suggests that this participant’s striatal volume was elevated prior to the age of 6 years. EOHD, Early-Onset HD; GNE, Gene-non-expanded; HD, Huntington Disease; ICV, Intracranial Volume; JOHD, Juvenile-Onset Huntington Disease
See this image and copyright information in PMC

References

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