Tecovirimat therapy for severe monkeypox infection: Longitudinal assessment of viral titers and clinical response pattern-A first case-series experience

Lennart Hermanussen¹, Ilka Grewe¹, Hui Ting Tang², Dominik Nörz², Lukas C Bal¹, Susanne Pfefferle², Stefan Unger³, Christian Hoffmann⁴, Dirk Berzow⁵, Matin Kohsar^{1

6}, Martin Aepfelbacher², Ansgar W Lohse^{1

7}, Marylyn M Addo^{1

7

8}, Marc Lütgehetmann^{2

7}, Julian Schulze Zur Wiesch^{1

7}, Stefan Schmiedel¹

Affiliations

¹ Department of Internal Medicine, Gastroenterology and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
³ Institute for interdisciplinary medicine (ifi), Hamburg, Germany.
⁴ ICH Hamburg-Stendal, Hamburg, Germany.
⁵ Praxis for Infectiology, Hamburg, Germany.
⁶ Department of Tropical Medicine Berhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
⁷ German Center for Infection Research, Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
⁸ Institute for Infection research and Vaccine development (IIRVD), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

Lennart Hermanussen et al. J Med Virol. 2023 Jan.

. 2023 Jan;95(1):e28181.

doi: 10.1002/jmv.28181. Epub 2022 Oct 20.

¹ Department of Internal Medicine, Gastroenterology and Hepatology, Sections of Infectious Diseases and Tropical Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
² Institute of Medical Microbiology, Virology and Hygiene, University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.
³ Institute for interdisciplinary medicine (ifi), Hamburg, Germany.
⁴ ICH Hamburg-Stendal, Hamburg, Germany.
⁵ Praxis for Infectiology, Hamburg, Germany.
⁶ Department of Tropical Medicine Berhard Nocht Institute for Tropical Medicine, Hamburg, Germany.
⁷ German Center for Infection Research, Hamburg-Lubeck-Borstel-Riems, Hamburg, Germany.
⁸ Institute for Infection research and Vaccine development (IIRVD), University Medical Center Hamburg-Eppendorf (UKE), Hamburg, Germany.

No abstract available

Comment in

Rapid improvement of severe Mpox lesions with oral tecovirimat.
Raccagni AR, Leoni D, Ciccullo A, Verdenelli S, Cattelan AM, Di Giambenedetto S, Falcone M, Mileto D, Castagna A, Nozza S. Raccagni AR, et al. J Med Virol. 2023 Jun;95(6):e28825. doi: 10.1002/jmv.28825. J Med Virol. 2023. PMID: 37246746 No abstract available.