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Multicenter Study
. 2022 Sep;50(9):3000605221126880.
doi: 10.1177/03000605221126880.

Target temperature management versus normothermia without temperature feedback systems for out-of-hospital cardiac arrest survivors

Hui Jai Lee  1   2 , Jonghwan Shin  1   2 , Kyoung Min You  1   2 , Woon Yong Kwon  2   3 , Kyung Su Kim  2   3 , You Hwan Jo  2   4 , Seung Min Park  2   4
Affiliations
Multicenter Study

Target temperature management versus normothermia without temperature feedback systems for out-of-hospital cardiac arrest survivors

Hui Jai Lee et al. J Int Med Res. 2022 Sep.

Abstract

Objective: The clinical benefit of automatic temperature control devices remains unclear. We investigated the outcomes of out-of-hospital cardiac arrest (OHCA) survivors who had undergone either target temperature management (TTM) with a temperature feedback system (TFS) or maintenance of normothermia without a TFS during post-resuscitation care.

Methods: This study was a retrospective analysis of a multicenter prospective cohort of OHCA survivors who had received postcardiac arrest care from August 2014 to December 2018. The overlap propensity score weighting method was applied for adjustment between groups.

Results: A total of 405 OHCA survivors were included. TTM with a TFS and normothermia without a TFS were applied to 318 and 87 patients, respectively. Fever events were more common in patients with normothermia without a TFS. After propensity score matching, no statistically significant differences were observed in the 1-month good neurologic outcome (odds ratio 0.99, 95% confidence interval [CI] 0.56-1.25) or survival rate (odds ratio 1.25, 95% CI 0.88-1.78).

Conclusion: No significant differences in the 1-month neurologic outcome were observed between patients receiving TTM with a TFS and those undergoing normothermia without a TFS.

Keywords: Out-of-hospital heart arrest; critical care; hypothermia; induced; target temperature management; temperature feedback system; treatment outcome.

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Conflict of interest statement

Declaration of conflicting interests: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Figure 1.
Figure 1.
Enrollment of study patients. OHCA: out-of-hospital cardiac arrest, DNAR: do not attempt resuscitation, CPC: cerebral performance category, ICU: intensive care unit, TTM: target temperature management, TFS: temperature feedback system.
Figure 2.
Figure 2.
Temperature of enrolled patients during initial 72 hours. Lines indicate the mean temperature of each group and shaded areas indicate the 2 SDs. TTM: target temperature management, SD: standard deviation.
Figure 3.
Figure 3.
Subgroup analysis for 1-month good neurologic outcomes (odds ratios and 95% confidence intervals). The x-axis represents the log (10) scale of the odds ratio of good neurologic outcomes between the groups.
See this image and copyright information in PMC

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