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Review
. 2022 Nov 30:221:115071.
doi: 10.1016/j.jpba.2022.115071. Epub 2022 Sep 22.

Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?

Amandine Dispas  1 , Pierre-Yves Sacré  2 , Eric Ziemons  2 , Philippe Hubert  2
Affiliations
Free article
Review

Emerging analytical techniques for pharmaceutical quality control: Where are we in 2022?

Amandine Dispas et al. J Pharm Biomed Anal. .
Free article

Abstract

Quality control is a fundamental and critical activity in the pharmaceutical industry that guarantees the quality of medicines. QC analyses are currently performed using several well-known techniques, mainly liquid and gas chromatography. However, current trends are focused on the development of new techniques to reduce analysis time and cost, to improve the performances and decrease ecological footprint. In this context, analytical scientists developed and studied emerging technologies based on spectroscopy and chromatography. The present review aims to give an overview of the recent development of vibrational spectroscopy, supercritical fluid chromatography and multi-dimensional chromatography. Selected emerging techniques are discussed using SWOT analysis and published pharmaceutical QC applications are discussed.

Keywords: Multidimensional chromatography; NIR spectroscopy; Pharmaceuticals; Quality control; Raman spectroscopy; Supercritical fluid chromatography; Vibrational spectroscopy.

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Conflict of interest statement

Declaration of Competing Interest The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Amandine DISPAS reports financial support was provided by European Commission. Amandine DISPAS reports financial support was provided by Walloon Public Service.

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