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Comment
. 2022 Sep 29;185(20):3645-3647.
doi: 10.1016/j.cell.2022.09.014.

Cerebrovasculature pumps up progenitors

Ryann M Fame  1
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Free article
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Cerebrovasculature pumps up progenitors

Ryann M Fame. Cell. .
Free article

Abstract

Fetal human brain stem cell niches that contain multipotent neural progenitors are progressively vascularized during development. Crouch et al. (Crouch et al., 2022) report endothelial and mural lineage trajectories that build developing prenatal vascular in second trimester fetal brain. This cerebral angiogenesis in neural progenitor zones occurs simultaneously with and can promote neurogenesis.

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Conflict of interest statement

Declaration of interests The authors have nothing to declare.

Comment on

  • Ensembles of endothelial and mural cells promote angiogenesis in prenatal human brain.
    Crouch EE, Bhaduri A, Andrews MG, Cebrian-Silla A, Diafos LN, Birrueta JO, Wedderburn-Pugh K, Valenzuela EJ, Bennett NK, Eze UC, Sandoval-Espinosa C, Chen J, Mora C, Ross JM, Howard CE, Gonzalez-Granero S, Lozano JF, Vento M, Haeussler M, Paredes MF, Nakamura K, Garcia-Verdugo JM, Alvarez-Buylla A, Kriegstein AR, Huang EJ. Crouch EE, et al. Cell. 2022 Sep 29;185(20):3753-3769.e18. doi: 10.1016/j.cell.2022.09.004. Cell. 2022. PMID: 36179668 Free PMC article.

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