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. 2022 Oct 10;40(10):1076-1078.
doi: 10.1016/j.ccell.2022.09.004. Epub 2022 Sep 29.

The importance of ancestry to understanding tumor mutation burden in cancer

Alexandra Snyder  1 , Nicholas McGranahan  2
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The importance of ancestry to understanding tumor mutation burden in cancer

Alexandra Snyder et al. Cancer Cell. .
Free article

Abstract

In the current issue of Cancer Cell, Nassar and colleagues find that in solid tumors, tumor-only sequencing leads to an overestimate of the biomarker tumor mutation burden (TMB), particularly in patients of African or Asian ancestry. Correction of the TMB estimate improves the correlation between TMB and response to immunotherapy.

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Conflict of interest statement

Declaration of interests N.M. has received consultancy fees and has stock options in Achilles Therapeutics. N.M. holds European patents relating to targeting neoantigens (PCT/EP2016/059401), identifying patient response to immune checkpoint blockade (PCT/EP2016/071471), determining Human Leukocyte Antigen loss of heterozygosity (PCT/GB2018/052004), and predicting survival rates of patients with cancer (PCT/GB2020/050221). A.S. was previously an employee of, and still holds stock in, Merck, Inc. A.S. is currently an employee of Generate Biomedicines.

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