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. 2022 Oct 10;40(10):1081-1083.
doi: 10.1016/j.ccell.2022.09.006. Epub 2022 Sep 29.

Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

Semanti Mukherjee  1 , Jian Carrot-Zhang  2
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Whole-genome sequencing of East Asian lung cancers reveals new germline pathogenic variants

Semanti Mukherjee et al. Cancer Cell. .
Free article

Abstract

In this issue of Cancer Cell, Wang et al. use whole-genome sequencing of lung cancer cases and controls with East Asian ancestry to comprehensively characterize both common and rare variants that predispose to lung cancer. Their findings suggest that rare promoter variants in BRCA2 are associated with increased lung cancer risk.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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  • Analyses of rare predisposing variants of lung cancer in 6,004 whole genomes in Chinese.
    Wang C, Dai J, Qin N, Fan J, Ma H, Chen C, An M, Zhang J, Yan C, Gu Y, Xie Y, He Y, Jiang Y, Zhu M, Song C, Jiang T, Liu J, Zhou J, Wang N, Hua T, Liang S, Wang L, Xu J, Yin R, Chen L, Xu L, Jin G, Lin D, Hu Z, Shen H. Wang C, et al. Cancer Cell. 2022 Oct 10;40(10):1223-1239.e6. doi: 10.1016/j.ccell.2022.08.013. Epub 2022 Sep 15. Cancer Cell. 2022. PMID: 36113475

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