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. 2022 Nov;22(11):1535-1537.
doi: 10.1016/S1473-3099(22)00642-9. Epub 2022 Sep 27.

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

Fanchong Jian  1 , Yuanling Yu  2 , Weiliang Song  3 , Ayijiang Yisimayi  3 , Lingling Yu  2 , Yuxue Gao  2 , Na Zhang  2 , Yao Wang  2 , Fei Shao  2 , Xiaohua Hao  4 , Yanli Xu  2 , Ronghua Jin  5 , Youchun Wang  6 , Xiaoliang Sunney Xie  7 , Yunlong Cao  8
Affiliations

Further humoral immunity evasion of emerging SARS-CoV-2 BA.4 and BA.5 subvariants

Fanchong Jian et al. Lancet Infect Dis. 2022 Nov.
No abstract available

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Conflict of interest statement

YC and XSX are co-founders of Singlomics Biopharmaceuticals and inventors of patents associated with SARS-CoV-2 neutralising antibodies. All other authors declare no competing interests. FJ and YY contributed equally.

Figures

Figure
Figure
Efficacy of convalescent plasma against BA.4 and BA.5 subvariants with mutations on spike Arg346 NT50 against SARS-CoV-2 Asp614Gly, BA.4 or BA.5, BA.5.9 (BA.4 or BA.5 + Arg346Ile), BA.4.6 (BA.4 or BA.5 + Arg346Thr), BA.4.7 (BA.4 or BA.5 + Arg346Ser) pseudovirus by plasma samples from individuals who received three doses of CoronaVac (N=40; A), and those who received three doses CoronaVac followed by BA.1 breakthrough infection (N=50; B), BA.2 breakthrough infection (N=39; C), or BA.5 breakthrough infection (N=8; D). Geometric mean titres are annotated above each group. NT50=50% neutralisation titres. ns=not significant. *p<0·05; †p<0·01; ‡p<0·001. P-values are calculated by two-tailed Wilcoxon singed-rank test of paired samples.
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References

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