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Review
. 2022 Dec 1;222(Pt B):1676-1687.
doi: 10.1016/j.ijbiomac.2022.09.209. Epub 2022 Sep 28.

Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond

Yasmine K Abd El Fattah  1 , Ahmed I Abulsoud  2 , Sherihan G AbdelHamid  3 , Nadia M Hamdy  4
Affiliations
Review

Interactome battling of lncRNA CCDC144NL-AS1: Its role in the emergence and ferocity of cancer and beyond

Yasmine K Abd El Fattah et al. Int J Biol Macromol. .

Abstract

Long non-coding RNAs (lncRNAs) were, once, viewed as "noise" for transcription. Recently, many lncRNAs are functionally linked to several human disorders, including cancer. Coiled-Coil Domain Containing 144 N-Terminal-Like antisense1 (CCDC144NL-AS1) is a newly discovered cytosolic lncRNA. Aberrant CCDC144NL-AS1 expression was discovered in hepatocellular carcinoma (HCC), ovarian cancer (OC), gastric cancer (GC), non-small cell lung cancer (NSCLC), and osteosarcoma. CCDC144NL-AS1 could be a promising prognostic biological marker and therapeutic target for cancer. In this review, we will collect and highlight the available information about CCDC144NL-AS1 role in various cancers. Moreover, we will discuss the diagnostic and prognostic utility of CCDC144NL-AS1 as a new molecular biomarker for several human malignancies, besides its potential therapeutic importance.

Keywords: CCDC144NL-AS1; Epigenetics; Non-coding RNA; cancer hallmarks; microRNA.

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Conflict of interest statement

Declaration of competing interest None. All authors read and approved the final manuscript.

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