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. 2022 Oct 3;11(10):7.
doi: 10.1167/tvst.11.10.7.

Corvis Biomechanical Factor Facilitates the Detection of Primary Angle Closure Glaucoma

Chien-Chih Chou  1   2   3   4 , Po-Jen Shih  5 , Chun-Yuan Wang  2 , Tzuu-Shuh Jou  1   6 , Jun-Peng Chen  7 , I-Jong Wang  1   8   9
Affiliations

Corvis Biomechanical Factor Facilitates the Detection of Primary Angle Closure Glaucoma

Chien-Chih Chou et al. Transl Vis Sci Technol. .

Abstract

Purpose: To characterize the corneal biomechanical properties of primary angle closure glaucoma (PACG) and to investigate the diagnostic performance of combining corneal biomechanical parameters and anterior segment parameters in detecting PACG.

Methods: This retrospective cross-sectional study evaluated 79 and 81 eyes of normal controls and patients with PACG, respectively. Corvis Biomechanical Factor (CBiF) and anterior chamber volume (ACV) were measured using the Corvis ST and Pentacam, respectively. We performed multivariable logistic regression, adjusted for age, sex, central corneal thickness, intraocular pressure, and ACV to evaluate the effect of CBiF on PACG. The area under the receiver operating curve (AUC) was calculated to compare the diagnostic performance of ACV, CBiF, and ACV-CBiF combination for detecting PACG.

Results: The median CBiF of the control and PACG groups was 6.61 (interquartile range [IQR], 6.39-6.88) and 6.20 (IQR, 5.93-6.48), respectively (P < 0.001). A lower CBiF, suggestive of decreased corneal biomechanical stability, increased the odds of PACG (odds ratio, 0.029; 95% confidence interval [CI], 0.003-0.266; P = 0.002) in the multivariable logistic regression model. The ACV-CBiF combination yielded the highest AUC (0.934; 95% CI, 0.882-0.968) compared with ACV alone (0.878; 95% CI, 0.823-0.928). The ACV-CBiF combination had significantly higher discriminatory ability than that of ACV alone (DeLong test, P = 0.004).

Conclusions: Lower CBiF and ACV may act as independent predictors for PACG. Combining ACV and CBiF may enhance detection of PACG.

Translational relevance: The combination of corneal biomechanical parameters and anterior segment parameters enhances the detection of PACG.

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Conflict of interest statement

Disclosure: C.-C. Chou, None; P.-J. Shih, None; C.-Y. Wang, None; T.-S. Jou, None; J.-P. Chen, None; I.-J. Wang, None

Figures

Figure.
Figure.
Receiver operating characteristic curve demonstrated the performance of ACV, CBiF, and ACV + CBiF in discriminating between patients with primary angle closure glaucoma and controls. ACV + CBiF exhibited the highest area under the receiver operating characteristic curve (0.934; 95% CI, 0.882–0.968) compared with ACV alone (0.878; 95% CI, 0.823–0.928) or CBiF alone (0.799; 95% CI, 0.726–0.860). ACV + CBiF had significantly higher discriminatory ability than that of ACV alone (DeLong test, P = 0.004) and the CBiF alone (DeLong test, P < 0.001).
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Comment in

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