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Comment
. 2022 Dec;18(12):675-676.
doi: 10.1038/s41584-022-00854-9.

Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils

Somanathapura K NaveenKumar  1 , Jason S Knight  2
Affiliations
Comment

Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils

Somanathapura K NaveenKumar et al. Nat Rev Rheumatol. 2022 Dec.

Abstract

Although neutrophils are vital components of the innate immune system, they can also contribute to the inflammation and autoantibody formation that characterize a number of rheumatic diseases. The ability to specifically target neutrophils, and in particular activated neutrophils, could enable the direct delivery of drugs for therapeutic modulation of neutrophil activity.

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Conflict of interest statement

The authors declare no competing interests

Figures

Fig. 1
Fig. 1. Illustration of therapeutic nanoparticle targeting.
Hydroxychloroquine (HCQ)-containing platelet-neutrophil-targeted nanoparticles (PNT-NP) are conjugated with a neutrophil elastase binding peptide (NEBP) derived from alpha-1 antitrypsin, which engages neutrophil elastase (NE) on activated neutrophils, and with P-selectin-binding peptide (PBP), which interacts with P-selectin on activated platelets. HCQ-PNT-NP have the potential to reduce thrombus formation.
See this image and copyright information in PMC

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References

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