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Meta-Analysis
. 2022 Sep 30;15(1):109.
doi: 10.1186/s13048-022-01041-w.

Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai #  1 , Xi Luo #  2 , Wei Wu  1 , Jianyuan Song  3 , Ning-Ning Xie  1 , Cuicui Duan  4 , Xiao-Ke Wu  5   6 , Jian Xu  7   8
Affiliations
Meta-Analysis

Metabolic differences in women with premature ovarian insufficiency: a systematic review and meta-analysis

Wang-Yu Cai et al. J Ovarian Res. .

Abstract

Objective: This review aimed to investigate the metabolic profile of women with premature ovarian insufficiency (POI) compared relative to women with normal ovarian functioning.

Methods: A systematic search of PubMed, EMBASE, and the Web of Science for observational studies published up until the 6th of July 2021 that compared the metabolic profile of POI women with a healthy control group were assessed. Mean differences (MD) and 95% confidence interval (CI) were pooled using the fixed or random effect models.

Results: A total of 21 studies involving 1573 women with POI and 1762 control women were included. POI patients presented significantly higher waist circumference, total cholesterol, low-density lipoprotein, high-density lipoprotein, triglycerides, and fasting glucose. Additionally, POI patients had marginally higher insulin level. However, the differences in systolic, and diastolic blood pressure were non-significant relative to the control group.

Conclusions: POI is associated with alterations in certain metabolic parameters compared to control women. This finding highlights the importance of early screening and the lifelong management of metabolic health for women with POI.

Keywords: Glucose; Lipid; Metabolic; Premature ovarian insufficiency; Systematic review.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Fig. 1
Fig. 1
Flowchart for selecting studies
Fig. 2
Fig. 2
Forest plot for the meta-analysis for waist circumference between premature ovarian insufficiency and control group
Fig. 3
Fig. 3
Forest plots for the meta-analysis for (A) systolic blood pressure and (B) diastolic blood pressure between premature ovarian insufficiency and control group
Fig. 4
Fig. 4
Forest plots for the meta-analysis for (A) fasting glucose and (B) insulin between premature ovarian insufficiency and control group
Fig. 5
Fig. 5
Forest plots for the meta-analysis for (A) total cholesterol, (B) high-density lipoprotein, (C) low-density lipoprotein and (D) triglycerides between premature ovarian insufficiency and control group
See this image and copyright information in PMC

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