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Review
. 2022 Dec;173(Pt A):105799.
doi: 10.1016/j.micpath.2022.105799. Epub 2022 Sep 28.

Monkeypox: Emerging virus of concern; antivirals and vaccines therapeutic options

Mohammad A Obeid  1 , Haneen Amawi  2 , Ahmed Alshehri  3 , Adedapo Adesokan  4
Affiliations
Review

Monkeypox: Emerging virus of concern; antivirals and vaccines therapeutic options

Mohammad A Obeid et al. Microb Pathog. 2022 Dec.

Abstract

The detection of >400 Monkeypox virus cases in the month of May 2022 and increase to 57,527. confirmed cases by September 9th, 2022, across the world, emphasizes the need of new therapeutics for this emerging viral epidemic in humans. Largely the cases seen in Europe, Australia and America are among men who have sex with men making transmission through intimate contact with infectious skin lesions the likely mode of transmission. This implies that this high human-to-human transmission observed in the young Caucasian clusters, and the probable community transmission without any history of travelling to endemic areas would suggest that the epidemic is likely to be sustained human-to-human transmission and unlikely one that would be a short-lasting epidemic. This might necessitate the need for new therapeutic approaches and agents for prophylaxis and treatment of acute infections which is the focus of this review article.

Keywords: Antiviral drugs; Epidemic; Monkeypox; Pandemic; Vaccines.

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Conflict of interest statement

Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Fig. 1
Fig. 1
Depicting typical pustules of Monkeypox human infection. Source: https://nigeriahealthwatch.com/accessed May 9th, 2022.
Fig. 2
Fig. 2
Chemical structure of Tecovirimat.
Fig. 3
Fig. 3
Chemical structure of Brincidofovir.
Image 1
See this image and copyright information in PMC

References

    1. Vivancos R., et al. Community transmission of monkeypox in the United Kingdom, April to may 2022. Euro Surveill. 2022;27(22) - PMC - PubMed
    1. government U. 2022. Monkeypox Cases Confirmed in England – Latest Updates.
    1. Nigeria, C., Situation Report: Monkeypox (MPX) in Nigeria.
    1. Petersen E., et al. Monkeypox—enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era. Int. J. Infect. Dis. 2019;78:78–84. - PMC - PubMed
    1. Likos A.M., et al. A tale of two clades: monkeypox viruses. J. Gen. Virol. 2005;86(10):2661–2672. - PubMed