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Meta-Analysis
. 2022 Oct 2;217 Suppl 7(Suppl 7):S7-S21.
doi: 10.5694/mja2.51680.

Effectiveness of nutrition and dietary interventions for people with serious mental illness: systematic review and meta-analysis

Tetyana Rocks  1 , Scott B Teasdale  2   3 , Caitlin Fehily  4 , Claire Young  5 , Gina Howland  5 , Blair Kelly  6 , Samantha Dawson  5 , Felice Jacka  5   7 , James A Dunbar  8 , Adrienne O'Neil  9
Affiliations
Meta-Analysis

Effectiveness of nutrition and dietary interventions for people with serious mental illness: systematic review and meta-analysis

Tetyana Rocks et al. Med J Aust. .

Abstract

Objective: To review recent published trials of nutrition and dietary interventions for people with serious mental illness; to assess their effectiveness in improving metabolic syndrome risk factors.

Study design: Systematic review and meta-analysis of randomised and non-randomised controlled trials of interventions with a nutrition/diet-related component delivered to people with serious mental illness, published 1 January 2010 - 6 September 2021. Primary outcomes were weight, body mass index (BMI), and waist circumference. Secondary outcomes were total serum cholesterol, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) cholesterol, triglyceride, and blood glucose levels.

Data sources: MEDLINE, EMBASE, PsycINFO, CINAHL, and CENTRAL databases. In addition, reference lists of relevant publications were examined for further additional studies.

Data synthesis: Twenty-five studies encompassing 26 intervention arms were included in our analysis. Eight studies were at low or some risk of bias, seventeen were deemed to be at high risk. Eight of seventeen intervention arms found statistically significant intervention effects on weight, ten of 24 on BMI, and seven of seventeen on waist circumference. The pooled effects of nutrition interventions on metabolic syndrome risk factors were statistically non-significant. However, we identified small size effects on weight for interventions delivered by dietitians (five studies; 262 intervention, 258 control participants; standardised mean difference [SMD], -0.28; 95% CI, -0.51 to -0.04) and interventions consisting of individual sessions only (three studies; 141 intervention, 134 control participants; SMD, -0.30; 95% CI, -0.54 to -0.06).

Conclusions: We found only limited evidence for nutrition interventions improving metabolic syndrome risk factors in people with serious mental illness. However, they may be more effective when delivered on an individual basis or by dietitians.

Prospero registration: CRD42021235979 (prospective).

Keywords: Diet; Metabolic diseases; Mood disorders; Nutrition; Schizophrenia spectrum and other psychotic disorders.

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Conflict of interest statement

No relevant disclosures.

Figures

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df = degrees of freedom; SD = standard deviation. ◆
None
df = degrees of freedom; HDL = high‐density lipoprotein; LDL = low‐density lipoprotein; SD = standard deviation. ◆
See this image and copyright information in PMC

References

    1. Vancampfort D, Stubbs B, Mitchell AJ, et al. Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder: a systematic review and meta‐analysis. World Psychiatry 2015; 14: 339‐347. - PMC - PubMed
    1. Correll CU, Solmi M, Veronese N, et al. Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large‐scale meta‐analysis of 3 211 768 patients and 113 383 368 controls. World Psychiatry 2017; 16: 163‐180. - PMC - PubMed
    1. Jones S, Howard L, Thornicroft G. “Diagnostic overshadowing”: worse physical health care for people with mental illness. Acta Psychiatr Scand 2008; 118: 169‐171. - PubMed
    1. Firth J, Rosenbaum S, Stubbs B, et al. Motivating factors and barriers towards exercise in severe mental illness: a systematic review and meta‐analysis. Psychol Med 2016; 46: 2869‐2881. - PMC - PubMed
    1. Correll CU, Detraux J, De Lepeleire J, De Hert M. Effects of antipsychotics, antidepressants and mood stabilizers on risk for physical diseases in people with schizophrenia, depression and bipolar disorder. World Psychiatry 2015; 14: 119‐136. - PMC - PubMed