Ketamine promotes adaption-induced orientation plasticity and vigorous network changes

Abstract

Adult primary visual cortex features well demonstrated orientation selectivities. However, the imposition of a non-preferred stimulus for many minutes (adaptation) or the application of an antidepressant drug, such as ketamine, shifts the peak of the tuning curve, assigning a novel selectivity to a neuron. The effect of ketamine on V1 neural circuitry is not yet ascertained. The present investigation explores (in control, post-adaptation, and following local ketamine application) the modification of orientation selectivities and its outcome on functional relationships between neurons in mouse and cat. Two main results are revealed. Electrophysiological neuronal responses of monocular stimulation show that in cells exhibiting large orientation shifts after adaptation, ketamine facilitates the cell's recovery. Whereas in units displaying small shifts following adaptation, the drug increases the magnitude of orientation shifts. In addition, pair-wise cross correlogram analyses show modifications of functional relationships between neurons revealing updated micro-circuits as a consequence of ketamine application. We report in cat but not in mouse, that ketamine significantly increases the connectivity rate, their strengths, and an enhancement of neuronal synchrony.

Keywords: Cross correlation; Ketamine; Orientation selectivity; Plasticity; Synchrony; Visual adaptation.