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Comment
. 2022 Oct 2;7(1):344.
doi: 10.1038/s41392-022-01204-7.

Opening the box of PANTHORA in Alzheimer's disease

Martin Korte  1   2 , Reinhard W Köster  3
Affiliations
Comment

Opening the box of PANTHORA in Alzheimer's disease

Martin Korte et al. Signal Transduct Target Ther. .
No abstract available

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PANTHOS Progression. This graphic depicts how poorly acidified autolysosomes (AL) (purple) congregate in the soma of neurons (left), pushing out the cell membrane to form petal like structures, so called PANTHOS (right). Lysosomes (Ly), the cells disassembly organelle, begin leaking proteases (pink) and Aβ fibrils (gray squiggles) aggregate in lysosomal tubules around the cell nucleus. By this means a packed neuron collides with nearby PANTHOS cells and ruptures (right), recruiting glia cells to turn the Aβ debris into larger plaques. pa-AL: poorly acidified AL; poorly acidified Lys (pa-Ly). Adapted after Lee et al., Nature Neuroscience, 2022
See this image and copyright information in PMC

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References

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