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Case Reports
. 2022 Sep 26;10(27):9790-9797.
doi: 10.12998/wjcc.v10.i27.9790.

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma: A case report and review of literature

Jing Chen  1 , Ming-Yuan Zhu  2 , Yan-Hua Huang  1 , Zhong-Cheng Zhou  1 , Yi-Yu Shen  1 , Quan Zhou  3 , Ming-Jian Fei  3 , Fan-Chuang Kong  1
Affiliations
Case Reports

Synchronous primary duodenal papillary adenocarcinoma and gallbladder carcinoma: A case report and review of literature

Jing Chen et al. World J Clin Cases. .

Abstract

Background: Synchronous primary cancers (SPCs) have become increasingly frequent over the past decade. However, the coexistence of duodenal papillary and gallbladder cancers is rare, and such cases have not been previously reported in the English literature. Here, we describe an SPC case with duodenal papilla and gallbladder cancers and its diagnosis and successful management.

Case summary: A 68-year-old Chinese man was admitted to our hospital with the chief complaint of dyspepsia for the past month. Contrast-enhanced computed tomography of the abdomen performed at the local hospital revealed dilatation of the bile and pancreatic ducts and a space-occupying lesion in the duodenal papilla. Endoscopy revealed a tumor protruding from the duodenal papilla. Pathological findings for the biopsied tissue revealed tubular villous growth with moderate heterogeneous hyperplasia. Surgical treatment was selected. Macroscopic examination of this surgical specimen revealed a 2-cm papillary tumor and another tumor protruding by 0.5 cm in the gallbladder neck duct. Intraoperative rapid pathology identified adenocarcinoma in the gallbladder neck duct and tubular villous adenoma with high-grade intraepithelial neoplasia and local canceration in the duodenal papilla. After an uneventful postoperative recovery, the patient was discharged without complications.

Conclusion: It is essential for clinicians and pathologists to maintain a high degree of suspicion while evaluating such synchronous cancers.

Keywords: Case report; Duodenal papillary adenocarcinoma; Gallbladder carcinoma; Surgical treatment; Synchronous primary cancers.

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Conflict of interest statement

Conflict-of-interest statement: All authors declare that they have no conflicts of interest.

Figures

Figure 1
Figure 1
Contrast-enhanced computed tomography of the abdomen. A: Space-occupying lesion in the duodenal papilla (orange arrowheads) and dilatation of the common bile duct (blue arrowheads); B: dilatation of extrahepatic bile duct (orange arrowheads).
Figure 2
Figure 2
Endoscopic biopsy. Tumor protruding from the duodenal papilla.
Figure 3
Figure 3
Histopathological findings of endoscopic biopsy. A: Tubular villous growth. B: Moderate heterogeneous hyperplasia.
Figure 4
Figure 4
Macroscopic appearance of the surgical specimen. Papillary tumor (red circle) and gallbladder neck duct tumor (yellow circle) were present in the specimen.
See this image and copyright information in PMC

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