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Review
. 2022;9(3):92-100.
doi: 10.1007/s40475-022-00255-8. Epub 2022 Sep 23.

Herpesvirus-Associated Encephalitis: an Update

Elizabeth Matthews  1 , J David Beckham  1   2 , Amanda L Piquet  1 , Kenneth L Tyler  1   2 , Lakshmi Chauhan  1 , Daniel M Pastula  1   3
Affiliations
Review

Herpesvirus-Associated Encephalitis: an Update

Elizabeth Matthews et al. Curr Trop Med Rep. 2022.

Abstract

Purpose of review: Herpesviruses are a leading cause of encephalitis worldwide. The article reviews the eight human herpesviruses with a focus on recent advances as they pertain to encephalitis.

Recent findings: Notable recent updates include the development of multiplex polymerase chain reaction (PCR)-based panels, which have improved access to PCR tests, especially in rural and resource-limited areas. Despite unchanged treatment recommendations, research is ongoing into novel therapies. There have been recent advances in vaccines, particularly for varicella zoster virus (VZV) which may impact neurologic complications. Finally, the recent discovery of an association between herpes encephalitis and post-infectious autoimmune encephalitis has had a critical impact on the fields of infectious and autoimmune neurology, though there remains much to learn.

Summary: Most herpesviruses are neurotropic and must be considered on the differential diagnosis for infectious encephalitis. This article describes recent advances in the diagnosis, treatment, complications, and management of these infections.

Keywords: Cytomegalovirus encephalitis; Epstein-Barr virus encephalitis; HHV6 encephalitis; Herpes encephalitis; Postinfectious autoimmune encephalitis; Varicella zoster virus encephalitis.

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Conflict of interest statement

Conflict of InterestsDr. Beckham receives research funding from Roche. Dr. Piquet has received research funding from the University of Colorado and Rocky Mountain MS Center; consulting fees from Genentech/Roche and Alexion. Dr. Piquet reports honorarium from MedLink and publication royalties from Springer. Drs. Matthews, Tyler, Chauhan, and Pastula have no relevant financial or nonfinancial interests to disclose.

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