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. 2022 Jul 29;27(3):577-582.
doi: 10.5603/RPOR.a2022.0026. eCollection 2022.

Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer

Josef Kovarik  1 , Charles Kelly  1 , Nick West  1 , Michael Drinnan  1 , Werner Dobrowsky  1 , Muhammad Shahid Iqbal  1
Affiliations

Shrinkage of the non-malignant prostate gland volume after receiving incidental radiotherapy for rectal cancer

Josef Kovarik et al. Rep Pract Oncol Radiother. .

Abstract

Background: The purpose of this study was to assess the impact of coincidental radiotherapy on the volume of the non-malignant prostate gland in rectal cancer patients treated with neo-adjuvant radiotherapy.

Materials and methods: In this retrospective analysis, thirty male patients with rectal cancer who had neoadjuvant radiotherapy met the inclusion criteria. These patients had pre-treatment magnetic resonance imaging (MRI) and at least one post-treatment MRI of the pelvis and the whole of their prostate volume received the full prescribed radiotherapy dose; 45 Gy in 25 fractions (n = 22), 45 Gy in 20 fractions (n = 4) and 25 Gy in 5 fractions (n = 4).

Results: The median age of this patient cohort was 66 years (range: 30-87). With a median interval between pre-treatment MRI and first MRI post-treatment of 2 months (range: 1-11), the mean prostate volume reduced from 36.1 cm3 [standard deviation (SD) 14.2] pre-radiotherapy to 31.3 cm3 (SD 13.0) post radiotherapy and this difference was significant (p = 0.0004).

Conclusion: Radiotherapy may cause shrinkage in volume of normal (non-malignant) prostate. Further research is required in this field, since these results may be of some comfort to men contemplating the consequences of radiotherapy on their quality of life. The authors suggest recording flow-rate and international prostate symptom score (IPSS) during rectal radiotherapy as a next step.

Keywords: benign disease; prostate hyperplasia; radiotherapy.

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Conflict of interest statement

Conflict of interest None declared.

Figures

Figure 1
Figure 1
A consort diagram of patient selection. MRI — magnetic resonance imaging; RT — radiation therapy
Figure 2
Figure 2
The relation of pre-treatment prostate volume with age. The line of best-fit indicates a volume growth rate of 1.25% per year
Figure 3
Figure 3
An example of a treatment plan with dose distribution shown and the prostate outlined
Figure 4
Figure 4
Changes in prostate volume between first and second time-points; A. The pre-and-post treatment volumes for each patient; B. A histogram of the changes in these patients
See this image and copyright information in PMC

References

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