Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Apr 21;22(4):241-243.
doi: 10.1177/15357597221097876. eCollection 2022 Jul-Aug.

Open the Window for the Cure of Dravet

Affiliations
Comment

Open the Window for the Cure of Dravet

Bin Gu. Epilepsy Curr. .
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic of seizure rescue efficacy using genetic reinstatement approaches starting at various developmental stages in mouse models of epileptic syndromes caused by pathogenicity of Mecp2, Scn1a, Syngap1, Fmr1, and Ube3a (distinct curves for audiogenic seizures and pro-epileptogenic phenotype). Arrowheads denote different developmental stages at the time of rescue.

Comment on

References

    1. Shmuely S, Sisodiya SM, Gunning WB, Sander JW, Thijs RD. Mortality in Dravet syndrome: A review. Epilepsy Behav 2016;64:69-74. - PubMed
    1. Higurashi N, Broccoli V, Hirose S. Genetics and gene therapy in Dravet syndrome. Epilepsy Behav 2021:108043. - PubMed
    1. Garg SK, Lioy DT, Cheval H, et al. Systemic delivery of MeCP2 rescues behavioral and cellular deficits in female mouse models of Rett syndrome. J Neurosci 2013;33(34):13612-13620. - PMC - PubMed
    1. Creson TK, Rojas C, Hwaun E, et al. Re-expression of SynGAP protein in adulthood improves translatable measures of brain function and behavior. Elife 2019;8:e46752. - PMC - PubMed
    1. Milazzo C, Mientjes EJ, Wallaard I, et al. Antisense oligonucleotide treatment rescues UBE3A expression and multiple phenotypes of an Angelman syndrome mouse model. JCI Insight 2021;6(15):e145991. - PMC - PubMed

LinkOut - more resources