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Review
. 2022 Sep 1:5:51-53.
doi: 10.1016/j.ijregi.2022.08.015. eCollection 2022 Dec.

Emerging Monkeypox virus and neuroinflammatory disorders

Marzia Puccioni-Sohler  1   2 , Carolina Marques de Oliveira  3 , Marcelo Namen  4 , Clarissa R Damaso  5
Affiliations
Review

Emerging Monkeypox virus and neuroinflammatory disorders

Marzia Puccioni-Sohler et al. IJID Reg. .

Abstract

Alarming situation: Monkeypox is a zoonosis caused by a double-stranded DNA virus. The virus was isolated in monkeys in 1958. The first human case was detected in Africa in 1970. It is endemic in western and central Africa. The infection has worried public health authorities around the world since May 2022 with the emergence of thousands of cases in non-African countries.

Objective: We discuss the neurological manifestations associated with monkeypox infection.

Rare and severe complications: Although in the current outbreak, the disease appears to be self-limiting, with predominance of focal skin lesions, complications may occur, mainly in children and immunosuppressed patients. Neurological manifestations such as encephalitis, convulsion, dizziness, pain, fatigue, visual alteration, photophobia, headache and myalgia were previously reported. Encephalitis may be due to viral invasion of the central nervous system or an immune-mediated process. In both situations, rapid recognition is extremely important with the investigation of the cerebrospinal fluid exam, which can demonstrate the local inflammatory reaction, specific IgM and, possibly viral detection, in addition to the imaging study.

Conclusions: We emphasize that health professionals should be alert to the emergence of neurological disorders associated with monkeypox infection in order to avoid sequelae and better characterize the current disease.

Keywords: Monkeypox; cerebrospinal fluid; encephalitis; neuroinflammatory disorders; neurological manifestations; pediatric.

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References

    1. Adler H, Gould S, Hine P, Snell LB, Wong W, Houlihan CF, et al. Clinical features and management of human monkeypox: a retrospective observational study in the UK. Lancet Infect Dis. 2022;22:e177. doi: 10.1016/S1473-3099(22)00372-3. - DOI - PMC - PubMed
    1. Sepehrinezhad A, Ashayeri Ahmadabad R, Sahab-Negah S. Monkeypox virus from neurological complications to neuroinvasive properties: current status and future perspectives. J Neurol. 2022;21:1–8. doi: 10.1007/s00415-022-11339-w. Online ahead of print. - DOI - PMC - PubMed
    1. Badenoch JB, Conti I, Rengasamy ER, Watson CJ, Butler M, Hussain Z, et al. Neurological and psychiatric presentations associated with human monkeypox virus infection: a systematic review and meta-analysis. [Preprint]. Available at: https://www.medrxiv.org/content/10.1101/2022.07.03.22277069v1. doi:10.1101/2022.07.03.22277069. - DOI - DOI - PMC - PubMed
    1. Bunge EM, Hoet B, Chen L, Lienert F, Weidenthaler H, Baer LR, Steffen R. The changing epidemiology of human monkeypox-A potential threat? A systematic review. PLoS Negl Trop Dis. 2022;16 doi: 10.1371/journal.pntd.0010141. - DOI - PMC - PubMed
    1. Center for Disease Control and Prevention 2022 Monkeypox Outbreak Global Map. https://www.cdc.gov/poxvirus/monkeypox/response/2022/index.html (accessed 19 August 2022).

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