Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Nov;22(11):767-779.
doi: 10.1007/s11910-022-01234-2. Epub 2022 Oct 3.

Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship

Affiliations
Review

Sleep and Stroke: Opening Our Eyes to Current Knowledge of a Key Relationship

Valerio Brunetti et al. Curr Neurol Neurosci Rep. 2022 Nov.

Abstract

Purpose of review: To elucidate the interconnection between sleep and stroke.

Recent findings: Growing data support a bidirectional relationship between stroke and sleep. In particular, there is strong evidence that sleep-disordered breathing plays a pivotal role as risk factor and concur to worsening functional outcome. Conversely, for others sleep disorders (e.g., insomnia, restless legs syndrome, periodic limb movements of sleep, REM sleep behavior disorder), the evidence is weak. Moreover, sleep disturbances are highly prevalent also in chronic stroke and concur to worsening quality of life of patients. Promising novel technologies will probably allow, in a near future, to guarantee a screening of commonest sleep disturbances in a larger proportion of patients with stroke. Sleep assessment and management should enter in the routinary evaluation of stroke patients, of both acute and chronic phase. Future research should focus on the efficacy of specific sleep intervention as a therapeutic option for stroke patients.

Keywords: Circadian rhythm; Insomnia; Restless legs syndrome; Sleep; Sleep apnea; Stroke.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interests/competing interests/funding to declare.

Figures

Fig. 1
Fig. 1
Sleep and its disorders strictly interconnected with stroke

References

    1. Hasan F, Gordon C, Wu D, Huang HC, Yuliana LT, Susatia B et al. Dynamic prevalence of sleep disorders following stroke or transient ischemic attack: systematic review and meta-analysis. Stroke. 2021;52(2):655–63. A systematic review and meta-analysis that evaluated the prevalence and evolution of main sleep disorders (sleep-disordered breathing, insomnia, restless legs syndrome, and periodic limb movements of sleep) from acute to chronic phase of stroke. - PubMed
    1. Seiler A, Camilo M, Korostovtseva L, Haynes AG, Brill AK, Horvath T, et al. Prevalence of sleep-disordered breathing after stroke and TIA: a meta-analysis. Neurology. 2019;92(7):e648–e654. - PubMed
    1. He Q, Zhang P, Li G, Dai H, Shi J. The association between insomnia symptoms and risk of cardio-cerebral vascular events: a meta-analysis of prospective cohort studies. Eur J Prev Cardiol. 2017;24(10):1071–1082. - PubMed
    1. Kendzerska T, Kamra M, Murray BJ, Boulos MI. Incident cardiovascular events and death in individuals with restless legs syndrome or periodic limb movements in sleep: a systematic review. Sleep. 2017;40(3):zsx013. doi: 10.1093/sleep/zsx013. - DOI - PubMed
    1. Ma C, Pavlova M, Liu Y, Liu Y, Huangfu C, Wu S, et al. Probable REM sleep behavior disorder and risk of stroke: a prospective study. Neurology. 2017;88(19):1849–1855. - PMC - PubMed

Publication types