Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Jan;20(1):155-159.
doi: 10.1513/AnnalsATS.202205-453RL.

Neuropathology Associated with Acute Respiratory Distress Syndrome: An Autopsy Study

Lucy Q Zhang  1 , Thomas D Zaikos  1 , Nivedha Kannapadi  1 , Lindsay Laws  1 , Pavan Shah  1 , Juan C Troncoso  1 , R Scott Stephens  1 , Paul Nyquist  1 , Sung-Min Cho  1
Affiliations

Neuropathology Associated with Acute Respiratory Distress Syndrome: An Autopsy Study

Lucy Q Zhang et al. Ann Am Thorac Soc. 2023 Jan.
No abstract available

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Representative brain autopsy findings of patients with ARDS. (A and B) Hypoxic ischemic brain injury (eosinophilic/red neurons) was the most common form of acute brain injury and could be identified focally, often in the hippocampus (A, arrows) and multifocally, also involving Purkinje cells in the cerebellum (B, arrows). (C) Subarachnoid hemorrhage was the most common subtype of intracranial hemorrhage identified. (D and E) Infarctions of varying chronicity were also observed. (F) Reactive changes, including Alzheimer type 2 astrocytes (arrowhead), were identified in a subset of patients. ARDS = acute respiratory distress syndrome.
See this image and copyright information in PMC

References

    1. Hopkins RO, Gale SD, Weaver LK. Brain atrophy and cognitive impairment in survivors of acute respiratory distress syndrome. Brain Inj . 2006;20:263–271. - PubMed
    1. Hopkins RO, Weaver LK, Pope D, Orme JF, Bigler ED, Larson-LOHR V. Neuropsychological sequelae and impaired health status in survivors of severe acute respiratory distress syndrome. Am J Respir Crit Care Med . 1999;160:50–56. - PubMed
    1. Kim JS, Kim YJ, Kim M, Ryoo SM, Sohn CH, Ahn S, et al. The impact of severity of acute respiratory distress syndrome following cardiac arrest on neurologic outcomes. Ther Hypothermia Temp Manag . 2021;11:96–102. - PubMed
    1. Sasannejad C, Ely EW, Lahiri S. Long-term cognitive impairment after acute respiratory distress syndrome: a review of clinical impact and pathophysiological mechanisms. Crit Care . 2019;23:352. - PMC - PubMed
    1. Rodríguez-González R, Ramos-Nuez Á, Martín-Barrasa JL, López-Aguilar J, Baluja A, Álvarez J, et al. Endotoxin-induced lung alveolar cell injury causes brain cell damage. Exp Biol Med (Maywood) . 2015;240:135–142. - PMC - PubMed

Publication types