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. 2022 Dec;44(1):1615-1621.
doi: 10.1080/0886022X.2022.2128373.

The triglyceride-glucose index as a novel marker associated with sarcopenia in non-diabetic patients on maintenance hemodialysis

Ruoxin Chen  1 , Liuping Zhang  1 , Mengyan Zhang  1 , Ying Wang  1 , Dan Liu  1 , Zuolin Li  1 , Xiaoliang Zhang  1 , Hui Jin  2 , Bicheng Liu  1 , Hong Liu  1
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The triglyceride-glucose index as a novel marker associated with sarcopenia in non-diabetic patients on maintenance hemodialysis

Ruoxin Chen et al. Ren Fail. 2022 Dec.

Abstract

Objective: Sarcopenia is a common complication in patients with end-stage kidney disease. Insulin resistance is present in non-diabetic patients undergoing maintenance hemodialysis (MHD) and is an important factor leading to sarcopenia. The triglyceride-glucose (TyG) index, a reliable indicator for evaluating insulin resistance, is widely used in clinical practice. The present study investigated the association between the TyG index and sarcopenia in non-diabetic patients undergoing MHD.

Methods: Relevant clinical data of non-diabetic patients undergoing MHD at our center were collected. The TyG index was calculated using the following formula: ln(fasting triglycerides(mg/dL)×fasting blood glucose(mg/dL)/2). Multivariate logistic regression analyses were used to evaluate the associations. The receiver-operating characteristic curve was used to analyze the predictive value of the TyG index in sarcopenia.

Results: Of the 142 patients undergoing MHD who were included, 75 (52.82%) were men, the mean age was 54.05 ± 13.97 years, and 40 (28.17%) patients satisfied the diagnostic criteria for sarcopenia. The TyG index of participants with sarcopenia was higher compared with those without sarcopenia (8.83 ± 0.45 vs. 8.49 ± 0.50, p < 0.001). The prevalence of sarcopenia increased with increasing TyG index tertile (T1, 8.51%; T2, 31.91%; T3, 43.75%; p = 0.001). Logistic regression analysis indicated that the TyG index was an independent risk factor for sarcopenia (odds ratio, 4.21 [95% confidence interval, 1.85-9.59], p = 0.001).

Conclusion: A higher TyG index was associated with an increased risk of sarcopenia in non-diabetic patients undergoing MHD; it may be used as a novel marker to reflect the presence of sarcopenia.

Keywords: Sarcopenia; insulin resistance; maintenance hemodialysis; non-diabetic; triglyceride-glucose index.

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Conflict of interest statement

No potential conflict of interest was reported by the author(s).

Figures

Figure 1.
Figure 1.
Prevalence of sarcopenia according to TyG index tertiles in non-diabetic patients on maintenance hemodialysis. Significant differences between groups are indicated by *(p < 0.05) and **(p < 0.001), and ns indicates no significant difference (p > 0.05).
Figure 2.
Figure 2.
Receiver-operating characteristics (ROC) curves of the TyG index (AUC = 0.707).
See this image and copyright information in PMC

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