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. 2023 Feb;164(2):289-292.e4.
doi: 10.1053/j.gastro.2022.09.036. Epub 2022 Oct 1.

Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Dongni Fu  1 , Brandon M Blobner  1 , Phil J Greer  1 , Robert Lafyatis  2 , Melena D Bellin  3 , David C Whitcomb  4 ; Prospective Autos Study; GREAT1 Study; North American Pancreatitis Study Group
Collaborators, Affiliations

Pancreatitis-Associated PRSS1-PRSS2 Haplotype Alters T-Cell Receptor Beta (TRB) Repertoire More Strongly Than PRSS1 Expression

Dongni Fu et al. Gastroenterology. 2023 Feb.
No abstract available

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Conflict of interest statement

Conflicts of Interest

The authors declare that there is no conflict of interest regarding the publication of this paper.

Figures

Figure 1.
Figure 1.
PRSS1 and SPINK1 expression profile. (A) UMAP of all pancreatic cell type clusters. (B) Violin plot of PRSS1 and SPINK1 in all pancreatic clusters. (C) Co-expression of PRSS1 and SPINK1 in all cell-clusters. (blue: PRSS1 expression, orange: SPINK1 expression, pink: co-expression) (D) UMAP of undifferentiated cells sub-cluster from D. Subclusters are numbered by cell amounts. Cluster 6 transcriptome analysis is in supplemental Table S1. (E) Violin plot of PRSS1 and SPINK1 in 9 clusters in undifferentiated cells (0–8). *denotes cluster 6 PRSS1 vs SPINK1 expression. (F) Co-expression of PRSS1 and SPINK1 in undifferentiated cells from panel D.
See this image and copyright information in PMC

References

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