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. 2022 Dec;49(6):379-383.
doi: 10.1111/iji.12601. Epub 2022 Oct 3.

Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations

Stéphanie Gomes Santos de Almeida  1 , Fabiana Batalha Knakcfuss  2 , Lívia Maria Assis  3 , Regina Celia Gonçalves de Sousa  3 , Tereza Azevedo Matuck  3 , Deise de Boni Monteiro de Carvalho  3 , Ricardo Luiz Dantas Machado  4 , Maria Angelica Arpon Marandino Guimarães  1 , Rafael Brandão Varella  4
Affiliations

Investigation of cytokine polymorphisms on viral infections after renal transplantation exhibit association between IFN-γ +874 A > T and CMV manifestations

Stéphanie Gomes Santos de Almeida et al. Int J Immunogenet. 2022 Dec.

Abstract

We investigated the effects of TNF-α, IFN-γ, IL-10 polymorphisms on viral infections (CMV, BKPyV, HHV-6, EBV) after renal transplantation. IFN-γ+874 A > T (lower IFN production) was associated with CMV disease (p = .039) in patients under mycophenolate-based therapy and graft failure (p = .025). This study underscores the role of IFN-γ+874 SNP in CMV infection.

Keywords: CMV; cytokine; polymorphism; transplant.

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