Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec;63(12):1307-1311.
doi: 10.1007/s00108-022-01408-7. Epub 2022 Oct 4.

[Refractory thrombotic thrombocytopenic purpura]

[Article in German]
K Herfurth  1 , J Ruhe  2 , K Kentouche  3 , A Günther  4 , D Brämer  4 , N Eckardt  5 , M Busch  2 , G Wolf  2
Affiliations

[Refractory thrombotic thrombocytopenic purpura]

[Article in German]
K Herfurth et al. Inn Med (Heidelb). 2022 Dec.

Abstract
in English, German

Thrombotic thrombocytopenic purpura (TTP) remains a serious illness with potentially life-threatening complications. The following case of a TTP patient describes a serious relapse with exacerbation in spite of adequately initiated therapy and highlights the necessity of interdisciplinary expertise in the treatment of the disease.

Eine thrombotisch-thrombozytopenische Purpura (TTP) ist, trotz erheblicher therapeutischer Fortschritte, ein schwerwiegendes Krankheitsbild mit potenziell lebensbedrohlichen Komplikationen. Der vorliegende Fall beschreibt ein schweres Rezidiv einer TTP mit Exazerbation trotz adäquat eingeleiteter Therapie und verdeutlicht die Notwendigkeit einer interdisziplinären Zusammenarbeit in der Behandlung der Erkrankung.

Keywords: ADAMTS13; Bortezomib; Caplacizumab; Stroke; Thrombotic microangiopathy.

PubMed Disclaimer

Similar articles

See all similar articles

References

    1. EMA (2018) Fachinformation Caplacizumab. https://www.ema.europa.eu/documents/product-information/cablivi-epar-pro.... Zugegriffen: 08.08.2022
    1. Lemiale V, Valade S, Mariotte E. Unresponsive thrombotic thrombocytopenic purpura (TTP): challenges and solutions. Ther Clin Risk Manag. 2021;17:577–587. doi: 10.2147/TCRM.S205632. - DOI - PMC - PubMed
    1. Page EE, et al. Thrombotic thrombocytopenic purpura: diagnostic criteria, clinical features, and long-term outcomes from 1995 through 2015. Blood Adv. 2017;1:590–600. doi: 10.1182/bloodadvances.2017005124. - DOI - PMC - PubMed
    1. Ruhe J, et al. Acquired thrombotic thrombocytopenic purpura after first vaccination dose of BNT162b2 mRNA COVID-19 vaccine. Ann Hematol. 2021;101(3):717–719. doi: 10.1007/s00277-021-04584-y. - DOI - PMC - PubMed
    1. Jokiranta TS, et al. Differential diagnosis of thrombotic microangiopathy in nephrology. BMC Nephrol. 2017;18:324. doi: 10.1186/s12882-017-0727-y. - DOI - PMC - PubMed

Publication types

LinkOut - more resources