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. 2022 Oct 4;10(10):CD009197.
doi: 10.1002/14651858.CD009197.pub5.

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis

Zelin Ye  1 , Yubin Cao  2 , Cheng Miao  3 , Wei Liu  4 , Li Dong  5 , Zongkai Lv  6 , Zipporah Iheozor-Ejiofor  7 , Chunjie Li  8
Affiliations

Periodontal therapy for primary or secondary prevention of cardiovascular disease in people with periodontitis

Zelin Ye et al. Cochrane Database Syst Rev. .

Abstract

Background: There may be an association between periodontitis and cardiovascular disease (CVD); however, the evidence so far has been uncertain about whether periodontal therapy can help prevent CVD in people diagnosed with chronic periodontitis. This is the third update of a review originally published in 2014, and most recently updated in 2019. Although there is a new multidimensional staging and grading system for periodontitis, we have retained the label 'chronic periodontitis' in this version of the review since available studies are based on the previous classification system.

Objectives: To investigate the effects of periodontal therapy for primary or secondary prevention of CVD in people with chronic periodontitis.

Search methods: An information specialist searched five bibliographic databases up to 17 November 2021 and additional search methods were used to identify published, unpublished, and ongoing studies. We also searched the Chinese BioMedical Literature Database, the China National Knowledge Infrastructure, the VIP database, and Sciencepaper Online to March 2022.

Selection criteria: We included randomised controlled trials (RCTs) that compared active periodontal therapy to no periodontal treatment or a different periodontal treatment. We included studies of participants with a diagnosis of chronic periodontitis, either with CVD (secondary prevention studies) or without CVD (primary prevention studies).

Data collection and analysis: Two review authors carried out the study identification, data extraction, and 'Risk of bias' assessment independently and in duplicate. They resolved any discrepancies by discussion, or with a third review author. We adopted a formal pilot-tested data extraction form, and used the Cochrane tool to assess the risk of bias in the studies. We used GRADE criteria to assess the certainty of the evidence.

Main results: There are no new completed RCTs on this topic since we published our last update in 2019. We included two RCTs in the review. One study focused on the primary prevention of CVD, and the other addressed secondary prevention. We evaluated both as being at high risk of bias. Our primary outcomes of interest were death (all-cause and CVD-related) and all cardiovascular events, measured at one-year follow-up or longer. For primary prevention of CVD in participants with periodontitis and metabolic syndrome, one study (165 participants) provided very low-certainty evidence. There was only one death in the study; we were unable to determine whether scaling and root planning plus amoxicillin and metronidazole could reduce incidence of all-cause death (Peto odds ratio (OR) 7.48, 95% confidence interval (CI) 0.15 to 376.98), or all CVD-related death (Peto OR 7.48, 95% CI 0.15 to 376.98). We could not exclude the possibility that scaling and root planning plus amoxicillin and metronidazole could increase cardiovascular events (Peto OR 7.77, 95% CI 1.07 to 56.1) compared with supragingival scaling measured at 12-month follow-up. For secondary prevention of CVD, one pilot study randomised 303 participants to receive scaling and root planning plus oral hygiene instruction (periodontal treatment) or oral hygiene instruction plus a copy of radiographs and recommendation to follow-up with a dentist (community care). As cardiovascular events had been measured for different time periods of between 6 and 25 months, and only 37 participants were available with at least one-year follow-up, we did not consider the data to be sufficiently robust for inclusion in this review. The study did not evaluate all-cause death and all CVD-related death. We are unable to draw any conclusions about the effects of periodontal therapy on secondary prevention of CVD.

Authors' conclusions: For primary prevention of cardiovascular disease (CVD) in people diagnosed with periodontitis and metabolic syndrome, very low-certainty evidence was inconclusive about the effects of scaling and root planning plus antibiotics compared to supragingival scaling. There is no reliable evidence available regarding secondary prevention of CVD in people diagnosed with chronic periodontitis and CVD. Further trials are needed to reach conclusions about whether treatment for periodontal disease can help prevent occurrence or recurrence of CVD.

Trial registration: ClinicalTrials.gov NCT04305171 NCT04785235 NCT04956211 NCT04012541.

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Conflict of interest statement

  1. Chunjie Li was supported by the 2011 Aubrey Sheiham Public Health & Primary Care Scholarship for the original version of this review, and finished the systematic review at the UK Cochrane Centre. He was supported by 2018 Sichuan University‐Luzhou Municipal Government Strategic Cooperation Research during the updating of the review. We declare that the research funding only provided financial support, without influencing any procedure or result of the review.

  2. Zelin Ye, Yubin Cao, Cheng Miao, Wei Liu, Li Dong, Zongkai Lv: none known

  3. Zipporah Iheozor‐Ejiofor: none known. Zipporah is an editor with Cochrane Oral Health but was not involved in the editorial process for this review.

Figures

1
1
Study flow diagram
2
2
Risk of bias summary: review authors' judgements about each risk of bias item for each included study
1.1
1.1. Analysis
Comparison 1: Primary prevention: SRP plus antibiotics versus supragingival scaling, Outcome 1: All‐cause death (12 months)
1.2
1.2. Analysis
Comparison 1: Primary prevention: SRP plus antibiotics versus supragingival scaling, Outcome 2: All CVD‐related death (12 months)
1.3
1.3. Analysis
Comparison 1: Primary prevention: SRP plus antibiotics versus supragingival scaling, Outcome 3: All cardiovascular events (12 months)
1.4
1.4. Analysis
Comparison 1: Primary prevention: SRP plus antibiotics versus supragingival scaling, Outcome 4: Adverse events (12 months)
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References to ongoing studies

ChiCTR2000036462 {unpublished data only}
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RBR‐66tr7h {published data only}56454016.6.0000.5419U1111‐1252‐2386
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References to other published versions of this review

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