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. 2022 Nov;43(11):891-893.
doi: 10.1016/j.tips.2022.09.003. Epub 2022 Oct 1.

GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction

Salvatore Nesci  1
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GPR35, ally of the anti-ischemic ATPIF1-ATP synthase interaction

Salvatore Nesci. Trends Pharmacol Sci. 2022 Nov.

Abstract

Mitochondrial ATP synthase synthesizes ATP for cellular functions; however, under various conditions, including ischemia, it hydrolyzes ATP, primarily to re-energize the mitochondria. ATP synthase inhibitory factor 1 (ATPIF1) inhibits hydrolysis of ATP by ATP synthase. Wyant and colleagues recently demonstrated that G-protein-coupled receptor 35 (GPR35) is involved in this process. This finding provides an additional framework for the novel discovery of potential therapeutic molecules against ischemia/reperfusion (I/R) injury.

Keywords: ATP inhibitory factor 1; ATP synthase; G-protein-coupled receptor 35; anti-ischemic interaction; kynurenic acid; mitochondria.

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Conflict of interest statement

Declaration of interests None declared by author.

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