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. 2022 Oct 4;20(1):448.
doi: 10.1186/s12967-022-03655-6.

Circulating hypoxia-dependent miR-210 is increased in clinical sepsis subtypes: A cohort study

Rachel E Powell  1 , Yi Yin Tai  2 , Jason N Kennedy  3   4 , Christopher W Seymour  3   4   5 , Stephen Y Chan  6
Affiliations

Circulating hypoxia-dependent miR-210 is increased in clinical sepsis subtypes: A cohort study

Rachel E Powell et al. J Transl Med. .
No abstract available

Keywords: Hypoxia; Sepsis; miR-210.

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Conflict of interest statement

S.Y.C. has served as a consultant for Acceleron Pharma and United Therapeutics. S.Y.C. is a director, officer, and shareholder in Synhale Therapeutics. S.Y.C. has held research grants from Actelion, Bayer, and Pfizer. S.Y.C. has filed patent applications regarding the targeting of metabolism in pulmonary hypertension. The other authors declare no competing interests.

Figures

Figure
Figure
Expression of miR-210 in patients with sepsis compared to control. Expression is increased in sepsis compared to control (red and blue vs. grey) and is further enriched in the delta subtype compared to non-delta sepsis (blue vs. red). P-values represent Tukey-corrected pairwise t-tests on log2-transformed data.
See this image and copyright information in PMC

References

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    1. Zhao J, Florentin J, Tai Y-Y, Torrino S, Ohayon L, Brzoska T, et al. Long Range Endocrine Delivery of Circulating miR-210 to Endothelium Promotes Pulmonary Hypertension. Circ Res. 2020 Aug 14;127(5):677–92. - PMC - PubMed

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