Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Sep 17;3(5):zqac049.
doi: 10.1093/function/zqac049. eCollection 2022.

Transient Receptor Potential Ankyrin 1 Channels in Inflammation and Cancer: Accelerators or Brakes?

Affiliations
Comment

Transient Receptor Potential Ankyrin 1 Channels in Inflammation and Cancer: Accelerators or Brakes?

Shuang Peng. Function (Oxf). .
No abstract available

Keywords: Ca2+ signaling; TRPA1; alcoholic pancreatitis; pancreatic fibrosis; pancreatic stellate cells.

PubMed Disclaimer

Figures

Figure 1.
Figure 1.
Schematic diagram illustrating that downregulation of TRPA1 in activated pancreatic stellate cells prevents the toxic Ca2+ signal generation that results in necrosis of quiescent stellate cells (see text for further explanation).

Comment on

References

    1. Talavera K, Startek JB, Alvarez-Collazo Jet al. Mammalian transient receptor potential TRPA1 channels: from structure to disease. Physiol Rev. 2020;100(2):725–803. - PubMed
    1. Bautista DM, Jordt S-E, Nikai Tet al. TRPA1 mediates the inflammatory actions of environmental irritants and proalgesic agents. Cell. 2006;124(6):1269–1282. - PubMed
    1. Bandell M, Story GM, Hwang SWet al. Noxious cold ion channel TRPA1 is activated by pungent compounds and bradykinin. Neuron. 2004;41(6):849–857. - PubMed
    1. Petersen OH. Bradykinin, COVID-19, and pancreatitis, a personal perspective. Function. 2021;2(5):zqab046. - PMC - PubMed
    1. Petersen OH, Gerasimenko JV, Gerasimenko OVet al. The roles of calcium and ATP in the physiology and pathology of the exocrine pancreas. Physiol Rev. 2021;101(4):1691–1744. - PubMed

Publication types