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Editorial
. 2022 Oct 5;12(10):2237-2239.
doi: 10.1158/2159-8290.CD-22-0845.

GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer

Zeribe C Nwosu  1 , Marina Pasca di Magliano  2   3
Affiliations
Editorial

GOT2: An Unexpected Mediator of Immunosuppression in Pancreatic Cancer

Zeribe C Nwosu et al. Cancer Discov. .

Abstract

In this issue, Abrego and colleagues describe an unexpected role for the mitochondrial enzyme glutamic-oxaloacetic transaminase (GOT2) in pancreatic cancer, whereby it acts as a nuclear fatty acid transporter binding to and activating the PPARδ nuclear receptor. In turn, the GOT2-PPARδaxis drives immunosuppression by suppressing T cell-mediated antitumor immunity. See related article by Abrego et al., p. 2414 (3).

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  • A Cancer Cell-Intrinsic GOT2-PPARδ Axis Suppresses Antitumor Immunity.
    Abrego J, Sanford-Crane H, Oon C, Xiao X, Betts CB, Sun D, Nagarajan S, Diaz L, Sandborg H, Bhattacharyya S, Xia Z, Coussens LM, Tontonoz P, Sherman MH. Abrego J, et al. Cancer Discov. 2022 Oct 5;12(10):2414-2433. doi: 10.1158/2159-8290.CD-22-0661. Cancer Discov. 2022. PMID: 35894778 Free PMC article.

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