Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2022 Sep 23;101(38):e30696.
doi: 10.1097/MD.0000000000030696.

Risk factors for postoperative delirium in elderly urological patients: A meta-analysis

Yaqi Hua  1 , Shoulin Chen  2 , Xiaoyun Xiong  3 , Chuyang Lin  4 , Dongying Li  5 , Ping Tu  6
Affiliations
Meta-Analysis

Risk factors for postoperative delirium in elderly urological patients: A meta-analysis

Yaqi Hua et al. Medicine (Baltimore). .

Abstract

Background: Avoiding postoperative delirium (POD) can have a significant detrimental effect on the rehabilitation and prognosis of elderly urological patients. It is necessary to explore the risk factors associated with POD in elderly urology to provide a basis for clinical recognition of delirium.

Methods: For relevant studies, we comprehensively searched Embase, MEDLINE, Ovid, PubMed, Scopus, The Cochrane Library, and Web of Science. The search deadline was September 2021.

Results: We identified 2046 studies, 8 of which were included in the ultimate analysis. A total of 8 articles, including 356 cases in the delirium group and 1813 cases in the non-delirium group, were included in the relevant literature. The 2 groups mentioned above differed significantly in the following factors: history of delirium (odds ratio [OR] = 6.98, 95% confidence interval [CI]: 1.63-29.86, P = .009); Preoperative use of psychotropic drugs (OR = 1.97, 95% CI: 1.11-3.52, P = .02); age (OR = 3.10, 95% CI: 2.08-4.12, P < .0001). The meta-analysis demonstrated that smoking, alcohol consumption, gender (male), mode of anesthesia (general anesthesia) and being unmarried did not have a significant effect on POD in elderly urological patients.

Conclusion: The risk factors for POD in elderly urological patients include history of delirium, preoperative use of psychotropic drugs, and age. The present study provides guidance for taking targeted preventive measures to reduce risks.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflicts of interest to disclose.

Figures

Figure 1.
Figure 1.
PRISMA flow diagram of study selection process. PRISMA = Preferred Reporting Items for Systematic Review and Meta-Analysis.
Figure 2.
Figure 2.
Cumulative meta-analysis of medical and disease factors on postoperative delirium related factors in elderly urological patients.
Figure 3.
Figure 3.
Cumulative meta-analysis of basic data on postoperative delirium related factors in elderly urological patients.
Figure 4.
Figure 4.
Cumulative meta-analysis of unhealthy lifestyle on postoperative delirium related factors in elderly urological patients.
Figure 5.
Figure 5.
Funnel offset diagram.
See this image and copyright information in PMC

References

    1. Poletajew S, Zapała P, Kopczyński B, et al. . Surgical treatment for renal masses in the elderly: analysis of oncological, surgical and functional outcomes. Int Braz J Urol. 2019;45:531–40. - PMC - PubMed
    1. Zhou Y, Wang J, Li X, et al. . Neuroprotectin D1 protects against postoperative delirium-like behavior in elderly mice. Front Aging Neurosci. 2020;12:582674. - PMC - PubMed
    1. Eschweiler GW, Czornik M, Herrmann ML, et al. . Presurgical screening improves risk prediction for delirium in elective surgery of older patients: the PAWEL RISK study. Front Aging Neurosci. 2021;13:679933. - PMC - PubMed
    1. Large MC, Reichard C, Williams JT, et al. . Incidence, risk factors, and complications of postoperative delirium in elderly patients undergoing radical cystectomy. Urology. 2013;81:123–8. - PubMed
    1. Tognoni P, Simonato A, Robutti N, et al. . Preoperative risk factors for postoperative delirium (POD) after urological surgery in the elderly. Arch Gerontol Geriat. 2011;52:e166–9. - PubMed

Publication types