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Editorial
. 2022 Dec 15;28(24):5235-5237.
doi: 10.1158/1078-0432.CCR-22-2664.

TP53 or Not TP53: That Is the Question

Steven D Green  1 , Joshua F Zeidner  2
Affiliations
Editorial

TP53 or Not TP53: That Is the Question

Steven D Green et al. Clin Cancer Res. .

Abstract

Azacitidine and venetoclax are a standard first-line regimen for patients with newly diagnosed unfit acute myeloid leukemia (AML). In a pooled subset analysis, TP53-mutated AML with poor-risk cytogenetics does not appear to benefit from the addition of venetoclax to azacitidine. This has clinical implications as these patients should be preferentially treated with alternative regimens. See related article by Pollyea et al., p. 5272.

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