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. 2023 Nov 1;33(6):1176-1182.
doi: 10.1093/mr/roac120.

Vitamin D status-associated postoperative complications in patients with hip dysplasia after periacetabular osteotomy: A case-control study

Kazuki Kitade  1   2 , Taro Mawatari  1   2 , Shoji Baba  1 , Reima Sueda  1 , Satoshi Hagio  1 , Shinya Kawahara  2 , Satoshi Ikemura  2 , Yasuharu Nakashima  2
Affiliations

Vitamin D status-associated postoperative complications in patients with hip dysplasia after periacetabular osteotomy: A case-control study

Kazuki Kitade et al. Mod Rheumatol. .

Abstract

Objectives: This study aimed to clarify the relationship between vitamin D status and complications after periacetabular osteotomy.

Methods: A total of 46 hips of 39 patients (3 men and 36 women; mean age at surgery, 41.0 years; mean postoperative follow-up duration, 63 months) were reviewed to obtain the following information: patients' serum 25-hydroxyvitamin D [25(OH)D] status, prevalence of postoperative delayed union of osteotomy sites in the greater trochanter (DUGT) and ischiopubic stress fractures (IPSFs), and risk factors.

Results: The mean serum 25(OH)D level was 11.9 ng/ml. DUGT and IPSF were found in four (10.3%) and three (7.7%) patients, respectively. Serum 25(OH)D levels ≤ 11 ng/ml were significantly associated with DUGT in female patients (p = .02). Serum 25(OH)D levels ≤ 9 ng/ml and smoking were significantly associated with IPSF (p = 0.01 and 0.02, respectively). Overall, 21.7% of patients with serum 25(OH)D levels ≤ 11 ng/ml developed at least one complication; no complications occurred when serum 25(OH)D levels were >11 ng/ml.

Conclusion: Severe vitamin D deficiency was highly prevalent in relatively young patients. Vitamin D deficiency and smoking were independent risk factors for postoperative complications. Proactive supplementation is advisable to reduce postoperative complications, especially in patients with serum 25(OH)D levels ≤ 11 ng/ml.

Keywords: Delayed union; periacetabular osteotomy; postoperative complications; stress fracture; vitamin D deficiency.

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