Comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk"

Mika Kivimäki^{1

2}, Aroon D Hingorani^{3

4

5

6}, Joni V Lindbohm^{1

2

7}

Affiliations

¹ Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
² Clinicum, University of Helsinki, Helsinki FIN-00014, Finland.
³ Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
⁴ UCL British Heart Foundation Research Accelerator, London WC1E 6BT, UK.
⁵ UCL National Institute of Health Research Biomedical Research Centre, London W1T 7DN, UK.
⁶ Health Data Research UK, London NW1 2BE, UK.
⁷ Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

Comment

Mika Kivimäki et al. Sci Transl Med. 2022.

. 2022 Oct 5;14(665):eabq4810.

doi: 10.1126/scitranslmed.abq4810. Epub 2022 Oct 5.

Mika Kivimäki^{1

2}, Aroon D Hingorani^{3

4

5

6}, Joni V Lindbohm^{1

2

7}

¹ Department of Epidemiology and Public Health, University College London, London WC1E 6BT, UK.
² Clinicum, University of Helsinki, Helsinki FIN-00014, Finland.
³ Institute of Cardiovascular Science, University College London, London WC1E 6BT, UK.
⁴ UCL British Heart Foundation Research Accelerator, London WC1E 6BT, UK.
⁵ UCL National Institute of Health Research Biomedical Research Centre, London W1T 7DN, UK.
⁶ Health Data Research UK, London NW1 2BE, UK.
⁷ Broad Institute, Massachusetts Institute of Technology and Harvard University, Cambridge, MA 02142, USA.

Abstract

A 27-protein signature has been proposed to predict cardiovascular disease, but its applicability in clinical decision-making remains unclear.

Response to comment on "A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk".
Williams SA, Ganz P. Williams SA, et al. Sci Transl Med. 2022 Oct 5;14(665):eadd1355. doi: 10.1126/scitranslmed.add1355. Epub 2022 Oct 5. Sci Transl Med. 2022. PMID: 36197965

A proteomic surrogate for cardiovascular outcomes that is sensitive to multiple mechanisms of change in risk.
Williams SA, Ostroff R, Hinterberg MA, Coresh J, Ballantyne CM, Matsushita K, Mueller CE, Walter J, Jonasson C, Holman RR, Shah SH, Sattar N, Taylor R, Lean ME, Kato S, Shimokawa H, Sakata Y, Nochioka K, Parikh CR, Coca SG, Omland T, Chadwick J, Astling D, Hagar Y, Kureshi N, Loupy K, Paterson C, Primus J, Simpson M, Trujillo NP, Ganz P. Williams SA, et al. Sci Transl Med. 2022 Apr 6;14(639):eabj9625. doi: 10.1126/scitranslmed.abj9625. Epub 2022 Apr 6. Sci Transl Med. 2022. PMID: 35385337