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Comment
. 2022 Oct 4;34(10):1422-1424.
doi: 10.1016/j.cmet.2022.09.006.

Dietary sugar lowers immunity and microbiota that protect against metabolic disease

Han Fang  1 , Fernando F Anhê  2 , Jonathan D Schertzer  3
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Free article
Comment

Dietary sugar lowers immunity and microbiota that protect against metabolic disease

Han Fang et al. Cell Metab. .
Free article

Abstract

Diet influences intestinal microbiota, inflammation, and metabolism. Kawano et al. show that dietary sugar engaged upper gut innate lymphoid cells to replace segmented filamentous bacteria with a pathobiont. Added sugar worsened early metabolic disease by lowering protective Th17 immunity, thereby promoting intestinal lipid absorption and obesity in high-fat-diet-fed mice.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

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