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Comment
. 2022 Oct 4;34(10):1426-1428.
doi: 10.1016/j.cmet.2022.09.014.

Cap CASP, not SCAP, to fight steatohepatitis

Wolfram Goessling  1
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Cap CASP, not SCAP, to fight steatohepatitis

Wolfram Goessling. Cell Metab. .
Free article

Abstract

Hepatic lipid synthesis through SREBP has recently been found to be regulated not only through the canonical pathway involving SCAP in response to sterol deficiency, but also through the PIDDosome and CASP2. In this issue, Kim et al. identify a novel interaction between these two pathways in diet-induced non-alcoholic steatohepatitis.

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Conflict of interest statement

Declaration of interests The author declares no competing interests.

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