Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2022 Oct 5;7(1):351.
doi: 10.1038/s41392-022-01186-6.

Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration

Zerina Kurtovic  1   2 , Camilla I Svensson  3 , Emerson Krock  1
Affiliations
Comment

Bugs improve nerve regeneration: fasting-induced, microbiome-derived metabolite enhances peripheral nerve regeneration

Zerina Kurtovic et al. Signal Transduct Target Ther. .
No abstract available

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
Mice receiving food ad libitum (AL) or as an intermittent fasting (IF) diet were subjected to sciatic nerve crush injury. IF led to enhanced nerve regeneration compared to AL feeding. IF was also associated with elevated serum levels of indole-3-propionic acid (IPA) and IPA-producing gram-positive bacteria in the gut. The IF-induced enhanced nerve regeneration was recapitulated with fecal matter transplants from IF mice to AL mice, gut recolonization with Clostridium sporogenes, an IPA-producing bacteria, and systemic IPA delivery. Systemic IPA delivery induced dorsal root ganglia neutrophil infiltration, which was required for IPA enhancement of nerve regeneration. The figure was created with biorender
See this image and copyright information in PMC

Comment on

  • The gut metabolite indole-3 propionate promotes nerve regeneration and repair.
    Serger E, Luengo-Gutierrez L, Chadwick JS, Kong G, Zhou L, Crawford G, Danzi MC, Myridakis A, Brandis A, Bello AT, Müller F, Sanchez-Vassopoulos A, De Virgiliis F, Liddell P, Dumas ME, Strid J, Mani S, Dodd D, Di Giovanni S. Serger E, et al. Nature. 2022 Jul;607(7919):585-592. doi: 10.1038/s41586-022-04884-x. Epub 2022 Jun 22. Nature. 2022. PMID: 35732737

References

    1. Serger, E. et al. The gut metabolite indole-3 propionate promotes nerve regeneration and repair. Nature607, 585–592 (2022). - PubMed
    1. Grinsell, D. & Keating, C. P. Peripheral nerve reconstruction after injury: a review of clinical and experimental therapies. Biomed. Res. Int. 2014, 698256 (2014). - PMC - PubMed
    1. Rodenhouse A, et al. Altered gut microbiota composition with antibiotic treatment impairs functional recovery after traumatic peripheral nerve crush injury in mice: effects of probiotics with butyrate producing bacteria. BMC Res. Notes. 2022;15:1–8. doi: 10.1186/s13104-022-05967-8. - DOI - PMC - PubMed
    1. Parisien M, et al. Acute inflammatory response via neutrophil activation protects against the development of chronic pain. Sci. Transl. Med. 2022;14:eabj9954. doi: 10.1126/scitranslmed.abj9954. - DOI - PMC - PubMed
    1. Mattson MP, Moehl K, Ghena N, Schmaedick M, Cheng A. Intermittent metabolic switching, neuroplasticity and brain health. Nat. Rev. Neurosci. 2018;19:81–94. doi: 10.1038/nrn.2017.156. - DOI - PMC - PubMed

Publication types

Grants and funding