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. 1987 Jul 31;146(2):884-8.
doi: 10.1016/0006-291x(87)90613-9.

NH2-terminal of gastrin-17 in duodenal ulcer disease: identification of progastrin-17

P C Kothary, A I Vinik
Free article

NH2-terminal of gastrin-17 in duodenal ulcer disease: identification of progastrin-17

P C Kothary et al. Biochem Biophys Res Commun. .
Free article

Abstract

Serum gastrin concentrations were measured using antisera with specificity for the carboxyl and amino terminus of gastrin-17 in 50 healthy subjects and 18 patients with active duodenal ulcer disease (DU). The amino terminal of gastrin-17 immunoreactivity was significantly higher in DU patients than in healthy subjects. NH2-terminus of gastrin-17 immunopurified material from serum of DU patients was subjected to Sephadex G50 column chromatography and eluates were monitored by an additional antiserum EG10 that recognizes COOH-terminally extended gastrin. Besides the NH2 terminal tridecapeptide of gastrin-17, COOH-terminally extended progastrin was found. This may reflect abnormal processing of gastrin in patients with active duodenal ulcer disease.

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